Description: Homo sapiens LIM homeobox 6 (LHX6), transcript variant 5, mRNA. RefSeq Summary (NM_001242335): This gene encodes a member of a large protein family that contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein has tandem LIM domains as well as a DNA-binding homeodomain. The protein functions as a transcription factor involved in embryogenesis and head development and is highly expressed in neural crest derived mesenchyme cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2017]. Transcript (Including UTRs) Position: hg19 chr9:124,964,856-124,984,019 Size: 19,164 Total Exon Count: 7 Strand: - Coding Region Position: hg19 chr9:124,967,039-124,979,380 Size: 12,342 Coding Exon Count: 6
ID:H0YN76_HUMAN DESCRIPTION: SubName: Full=LIM/homeobox protein Lhx6; SUBCELLULAR LOCATION: Nucleus (By similarity). CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on H0YN76
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.