Human Gene BNC1 (ENST00000345382.7) from GENCODE V44
Description: Homo sapiens basonuclin 1 (BNC1), transcript variant 1, mRNA. (from RefSeq NM_001717) RefSeq Summary (NM_001717): The protein encoded by this gene is a zinc finger protein present in the basal cell layer of the epidermis and in hair follicles. It is also found in abundance in the germ cells of testis and ovary. This protein is thought to play a regulatory role in keratinocyte proliferation and it may also be a regulator for rRNA transcription. Alternative splicing of this gene results in multiple transcript variants, and multiple polyadenylation sites are indicated.[provided by RefSeq, Jul 2014]. Gencode Transcript: ENST00000345382.7 Gencode Gene: ENSG00000169594.14 Transcript (Including UTRs) Position: hg38 chr15:83,255,884-83,284,664 Size: 28,781 Total Exon Count: 5 Strand: - Coding Region Position: hg38 chr15:83,257,442-83,284,628 Size: 27,187 Coding Exon Count: 5
ID:BNC1_HUMAN DESCRIPTION: RecName: Full=Zinc finger protein basonuclin-1; FUNCTION: Likely to be a transcription factor specific for squamous epithelium and for the constituent keratinocytes at a stage either prior to or at the very beginning of terminal differentiation. May play a role in the differentiation of spermatozoa and oocytes. SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By similarity). Note=Relocates to the midpiece of the flagellum during late spermiogenesis in spermatids (By similarity). TISSUE SPECIFICITY: Expressed in epidermis, testis and foreskin, and to a lower extent in thymus, spleen, mammary glands, placenta, brain and heart. PTM: Phosphorylation on Ser-537 and Ser-541 leads to cytoplasmic localization. SIMILARITY: Contains 6 C2H2-type zinc fingers.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q01954
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0046872 metal ion binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0007283 spermatogenesis GO:0008284 positive regulation of cell proliferation GO:0008544 epidermis development GO:0030154 cell differentiation
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