Human Gene ZWINT (ENST00000373944.8) from GENCODE V44
Description: Homo sapiens ZW10 interacting kinetochore protein (ZWINT), transcript variant 1, mRNA. (from RefSeq NM_007057) RefSeq Summary (NM_007057): This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000373944.8 Gencode Gene: ENSG00000122952.17 Transcript (Including UTRs) Position: hg38 chr10:56,357,227-56,361,259 Size: 4,033 Total Exon Count: 9 Strand: - Coding Region Position: hg38 chr10:56,358,418-56,361,236 Size: 2,819 Coding Exon Count: 8
ID:ZWINT_HUMAN DESCRIPTION: RecName: Full=ZW10 interactor; AltName: Full=ZW10-interacting protein 1; Short=Zwint-1; FUNCTION: Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase. SUBUNIT: Interacts with ZW10 and MIS12. Interacts with the NDC80 subunit of the NDC80 complex specifically during mitosis. Also interacts with CASC5, CETN3, DSN1 and PMF1. INTERACTION: O14777:NDC80; NbExp=11; IntAct=EBI-1001132, EBI-715849; O43264:ZW10; NbExp=6; IntAct=EBI-1001132, EBI-1001217; SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
ModBase Predicted Comparative 3D Structure on O95229
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.