Human Gene TAS1R1 (ENST00000333172.11) from GENCODE V44
Description: Homo sapiens taste 1 receptor member 1 (TAS1R1), transcript variant 2, mRNA. (from RefSeq NM_138697) RefSeq Summary (NM_138697): The protein encoded by this gene is a G protein-coupled receptor and is a component of the heterodimeric amino acid taste receptor T1R1+3. The T1R1+3 receptor responds to L-amino acids but not to D-enantiomers or other compounds. Most amino acids that are perceived as sweet activate T1R1+3, and this activation is strictly dependent on an intact T1R1+3 heterodimer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]. Gencode Transcript: ENST00000333172.11 Gencode Gene: ENSG00000173662.21 Transcript (Including UTRs) Position: hg38 chr1:6,555,307-6,579,755 Size: 24,449 Total Exon Count: 6 Strand: + Coding Region Position: hg38 chr1:6,555,374-6,579,584 Size: 24,211 Coding Exon Count: 6
ID:TS1R1_HUMAN DESCRIPTION: RecName: Full=Taste receptor type 1 member 1; AltName: Full=G-protein coupled receptor 70; Flags: Precursor; FUNCTION: Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses. SUBUNIT: Forms heterodimers with TAS1R3. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily. SEQUENCE CAUTION: Sequence=AAL91359.1; Type=Erroneous initiation; Sequence=AAL91360.1; Type=Erroneous initiation; Sequence=AAL91361.1; Type=Erroneous initiation; Sequence=BAC05845.1; Type=Erroneous gene model prediction; WEB RESOURCE: Name=Protein Spotlight; Note=The taste experience - Issue 55 of February 2005; URL="http://web.expasy.org/spotlight/back_issues/sptlt055.shtml";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00003 - 7 transmembrane sweet-taste receptor of 3 GCPR PF01094 - Receptor family ligand binding region PF07562 - Nine Cysteines Domain of family 3 GPCR
ModBase Predicted Comparative 3D Structure on Q7RTX1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC136515 - Homo sapiens taste receptor, type 1, member 1, mRNA (cDNA clone MGC:168128 IMAGE:9020505), complete cds. BC136516 - Homo sapiens taste receptor, type 1, member 1, mRNA (cDNA clone MGC:168129 IMAGE:9020506), complete cds. AK315805 - Homo sapiens cDNA, FLJ96929, highly similar to Homo sapiens taste receptor, type 1, member 1 (TAS1R1), mRNA. AK292014 - Homo sapiens cDNA FLJ77460 complete cds, highly similar to Homo sapiens taste receptor, type 1, member 1 (TAS1R1), transcript variant 3, mRNA. AK293499 - Homo sapiens cDNA FLJ52254 complete cds, highly similar to Homo sapiens taste receptor, type 1, member 1 (TAS1R1), transcript variant 3, mRNA. AF387618 - Homo sapiens gm148 form B mRNA, complete cds, alternatively spliced. AF387617 - Homo sapiens gm148 form A mRNA, complete cds, alternatively spliced. AF387619 - Homo sapiens gm148 form C mRNA, partial cds, alternatively spliced. AF387620 - Homo sapiens gm148 form D mRNA, partial cds, alternatively spliced. DQ592253 - Homo sapiens piRNA piR-59365, complete sequence. JD182763 - Sequence 163787 from Patent EP1572962. JD279242 - Sequence 260266 from Patent EP1572962. JD554767 - Sequence 535791 from Patent EP1572962. JD180944 - Sequence 161968 from Patent EP1572962. JD426036 - Sequence 407060 from Patent EP1572962. JD411119 - Sequence 392143 from Patent EP1572962. JD254260 - Sequence 235284 from Patent EP1572962. JD219206 - Sequence 200230 from Patent EP1572962. JD075277 - Sequence 56301 from Patent EP1572962. JD162932 - Sequence 143956 from Patent EP1572962. JD257835 - Sequence 238859 from Patent EP1572962. JD046289 - Sequence 27313 from Patent EP1572962. JD046290 - Sequence 27314 from Patent EP1572962. JD090542 - Sequence 71566 from Patent EP1572962. JD268044 - Sequence 249068 from Patent EP1572962. JD081458 - Sequence 62482 from Patent EP1572962. JD382260 - Sequence 363284 from Patent EP1572962. JD100257 - Sequence 81281 from Patent EP1572962. JD056793 - Sequence 37817 from Patent EP1572962. JD056794 - Sequence 37818 from Patent EP1572962. JD138900 - Sequence 119924 from Patent EP1572962. JD138901 - Sequence 119925 from Patent EP1572962. JD385290 - Sequence 366314 from Patent EP1572962. JD489953 - Sequence 470977 from Patent EP1572962. JD204991 - Sequence 186015 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04742 - Taste transduction
Reactome (by CSHL, EBI, and GO)
Protein Q7RTX1 (Reactome details) participates in the following event(s):
R-HSA-444705 T1R1/T1R3 dimer is the umami taste receptor R-HSA-749454 The Ligand:GPCR:Gi complex dissociates R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-418594 G alpha (i) signalling events R-HSA-500792 GPCR ligand binding R-HSA-388396 GPCR downstream signalling R-HSA-372790 Signaling by GPCR R-HSA-162582 Signal Transduction