ID:THMS2_HUMAN DESCRIPTION: RecName: Full=Protein THEMIS2; AltName: Full=Induced by contact to basement membrane 1 protein; Short=Protein ICB-1; AltName: Full=Thymocyte-expressed molecule involved in selection protein 2; FUNCTION: May constitute a control point in macrophage inflammatory response, promoting LPS-induced TNF production. SUBUNIT: When phosphorylated, interacts with LYN. Interacts with VAV1 and GRB2 (By similarity). TISSUE SPECIFICITY: Expressed in different endometrial adenocarcinoma cell lines and various other cell lines apart from the prostate cell line LNCaP and the ovarian cancer cell line BG1. INDUCTION: By contact to a reconstituted basement membrane. PTM: Phosphorylation at Tyr-632 is induced by LPS (By similarity). SIMILARITY: Belongs to the themis family. SEQUENCE CAUTION: Sequence=AAC16284.1; Type=Frameshift; Positions=416, 469, 494, 530, 532; Sequence=BAA96464.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB33313.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAG64201.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAI21769.1; Type=Erroneous gene model prediction; Sequence=CAI21771.1; Type=Erroneous gene model prediction; Sequence=CAI21773.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q5TEJ8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.