Human Gene PTPRU (ENST00000345512.7) from GENCODE V44
Description: Homo sapiens protein tyrosine phosphatase receptor type U (PTPRU), transcript variant 3, mRNA. (from RefSeq NM_005704) RefSeq Summary (NM_005704): The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in cell-cell recognition and adhesion. Studies of the similar gene in mice suggested the role of this PTP in early neural development. The expression of this gene was reported to be regulated by phorbol myristate acetate (PMA) or calcium ionophore in Jurkat T lymphoma cells. Alternatively spliced transcript variants have been reported. [provided by RefSeq, Aug 2010]. Gencode Transcript: ENST00000345512.7 Gencode Gene: ENSG00000060656.20 Transcript (Including UTRs) Position: hg38 chr1:29,236,516-29,325,661 Size: 89,146 Total Exon Count: 31 Strand: + Coding Region Position: hg38 chr1:29,236,645-29,325,661 Size: 89,017 Coding Exon Count: 31
ID:PTPRU_HUMAN DESCRIPTION: RecName: Full=Receptor-type tyrosine-protein phosphatase U; Short=R-PTP-U; EC=3.1.3.48; AltName: Full=Pancreatic carcinoma phosphatase 2; Short=PCP-2; AltName: Full=Protein-tyrosine phosphatase J; Short=PTP-J; Short=hPTP-J; AltName: Full=Protein-tyrosine phosphatase pi; Short=PTP pi; AltName: Full=Protein-tyrosine phosphatase receptor omicron; Short=PTP-RO; AltName: Full=Receptor-type protein-tyrosine phosphatase psi; Short=R-PTP-psi; Flags: Precursor; FUNCTION: Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis. CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. SUBUNIT: Forms homooligomeric complexes which mediate cell homotypic adhesion (Probable). Interacts (via the cytoplasmic juxtamembrane domain) with CTNNB1; may mediate interaction with the cadherin/catenin adhesion complex. Interacts with KIT. May interact with AP3B1. SUBCELLULAR LOCATION: Cell junction. Cell membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: High levels in brain, pancreas, and skeletal muscle; less in colon, kidney, liver, stomach, and uterus; not expressed in placenta and spleen. Also detected in heart, prostate, lung, thymus, testis and ovary. Ubiquitously expressed in brain. Expressed by hematopoietic stem cells. DEVELOPMENTAL STAGE: Expressed in fetal brain, lung and kidney. INDUCTION: Up-regulated upon cell contact (at protein level). Down-regulated by phorbol ester (at protein level) and calcium ionophore but up-regulated by phorbol ester in megakaryocytic cells (PubMed:10397721). PTM: The extracellular domain is proteolytically processed through cleavage within the fibronectin type-III 4 domain (By similarity). Beside the 190 kDa full-length protein, proteolytic products of 100 kDa, 80 kDa and 73 kDa are observed. PTM: N-glycosylated. PTM: Phosphorylated on tyrosine residues upon activation of KIT with stem cell factor (SCF). The 73 kDa proteolytic product is not phosphorylated. SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily. SIMILARITY: Contains 4 fibronectin type-III domains. SIMILARITY: Contains 1 Ig-like C2-type (immunoglobulin-like) domain. SIMILARITY: Contains 1 MAM domain. SIMILARITY: Contains 2 tyrosine-protein phosphatase domains. SEQUENCE CAUTION: Sequence=CAA65016.1; Type=Miscellaneous discrepancy; Note=Several sequencing problems; Sequence=CAA65832.1; Type=Miscellaneous discrepancy; Note=Several sequencing problems;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00041 - Fibronectin type III domain PF00629 - MAM domain, meprin/A5/mu PF00102 - Protein-tyrosine phosphatase
ModBase Predicted Comparative 3D Structure on Q92729
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
