Human Gene MRPL37 (ENST00000360840.9) from GENCODE V44
Description: Homo sapiens mitochondrial ribosomal protein L37 (MRPL37), transcript variant 2, mRNA; nuclear gene for mitochondrial product. (from RefSeq NM_016491) RefSeq Summary (NM_016491): Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000360840.9 Gencode Gene: ENSG00000116221.15 Transcript (Including UTRs) Position: hg38 chr1:54,200,167-54,218,383 Size: 18,217 Total Exon Count: 7 Strand: + Coding Region Position: hg38 chr1:54,200,244-54,218,249 Size: 18,006 Coding Exon Count: 7
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF07147 - Mitochondrial 28S ribosomal protein S30 (PDCD9)
ModBase Predicted Comparative 3D Structure on Q9BZE1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK024572 - Homo sapiens cDNA: FLJ20919 fis, clone ADSE00849, highly similar to AF151069 Homo sapiens HSPC235 mRNA. AK026171 - Homo sapiens cDNA: FLJ22518 fis, clone HRC12216, highly similar to AF151069 Homo sapiens HSPC235 mRNA. AF151069 - Homo sapiens HSPC235 mRNA, complete cds. AF325707 - Homo sapiens ribosomal protein L2 (RPML2) mRNA, complete cds; nuclear gene for mitochondrial product. AY421759 - Homo sapiens mitochondrial ribosomal protein L37 variant 2 (MRPL37) mRNA, complete cds, alternatively spliced; nuclear gene for mitochondrial product. BC000041 - Homo sapiens mitochondrial ribosomal protein L37, mRNA (cDNA clone MGC:878 IMAGE:3505543), complete cds. CU674006 - Synthetic construct Homo sapiens gateway clone IMAGE:100018250 5' read MRPL37 mRNA. HQ447222 - Synthetic construct Homo sapiens clone IMAGE:100070523; CCSB003526_03 mitochondrial ribosomal protein L37 (MRPL37) gene, encodes complete protein. KJ898868 - Synthetic construct Homo sapiens clone ccsbBroadEn_08262 MRPL37 gene, encodes complete protein. DQ590382 - Homo sapiens piRNA piR-57494, complete sequence. JD436426 - Sequence 417450 from Patent EP1572962. JD131924 - Sequence 112948 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9BZE1 (Reactome details) participates in the following event(s):
R-HSA-5389839 39S subunit binds 28S subunit:mRNA:fMet-tRNA R-HSA-5419273 Hydrolysis of GTP and dissociation of 28S and 39S subunits R-HSA-5389848 TUFM:GTP:aminoacyl-tRNA binds 55S ribosome:mRNA:fMet-tRNA R-HSA-5389857 Peptide transfer from P-site to A-site (peptide bond formation) R-HSA-5389842 TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome R-HSA-5419261 55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP R-HSA-5419281 MRRF binds 55S ribosome:mRNA:tRNA R-HSA-5419279 Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA) R-HSA-5419264 MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA R-HSA-5419277 GFM2:GTP binds 55S ribosome:mRNA:tRNA:MRRF releasing mRNA and tRNA R-HSA-5368286 Mitochondrial translation initiation R-HSA-5419276 Mitochondrial translation termination R-HSA-5368287 Mitochondrial translation R-HSA-5389840 Mitochondrial translation elongation R-HSA-72766 Translation R-HSA-392499 Metabolism of proteins
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