Human Gene DNAJB4 (ENST00000370763.6) from GENCODE V44
Description: Homo sapiens DnaJ heat shock protein family (Hsp40) member B4 (DNAJB4), transcript variant 1, mRNA. (from RefSeq NM_007034) RefSeq Summary (NM_007034): The protein encoded by this gene is a molecular chaperone, tumor suppressor, and member of the heat shock protein-40 family. The encoded protein binds the cell adhesion protein E-cadherin and targets it to the plasma membrane. This protein also binds incorrectly folded E-cadherin and targets it for endoplasmic reticulum-associated degradation. This gene is a strong tumor suppressor for colorectal carcinoma, and downregulation of it may serve as a good biomarker for predicting patient outcomes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]. Gencode Transcript: ENST00000370763.6 Gencode Gene: ENSG00000162616.9 Transcript (Including UTRs) Position: hg38 chr1:78,004,939-78,017,964 Size: 13,026 Total Exon Count: 3 Strand: + Coding Region Position: hg38 chr1:78,005,111-78,016,247 Size: 11,137 Coding Exon Count: 3
ID:DNJB4_HUMAN DESCRIPTION: RecName: Full=DnaJ homolog subfamily B member 4; AltName: Full=Heat shock 40 kDa protein 1 homolog; Short=HSP40 homolog; Short=Heat shock protein 40 homolog; AltName: Full=Human liver DnaJ-like protein; FUNCTION: Probable chaperone. SUBUNIT: Homodimer. The C-terminal section interacts with the C- terminal tail of OPRM1. Interacts also with SDIM1. SUBCELLULAR LOCATION: Cytoplasm. Cell membrane. Note=Cytoplasmic according to PubMed:18837411 and membrane-associated according to PubMed:16542645. TISSUE SPECIFICITY: Expressed in heart, pancreas and skeletal muscle, and to a lesser extent in brain, placenta and liver. INDUCTION: By heat shock. SIMILARITY: Contains 1 J domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UDY4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006457 protein folding GO:0006986 response to unfolded protein GO:0009408 response to heat GO:0032781 positive regulation of ATPase activity
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Sequence and Links to Tools and Databases 
Microarray Expression Data 
