Human Gene INKA2 (ENST00000357260.6) from GENCODE V49

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Description: inka box actin regulator 2, transcript variant 2 (from RefSeq NM_198926.2)
Gencode Transcript: ENST00000357260.6
Gencode Gene: ENSG00000197852.12
Transcript (Including UTRs)
Position: hg38 chr1:111,722,064-111,739,395 Size: 17,332 Total Exon Count: 2 Strand: -
Coding Region
Position: hg38 chr1:111,726,968-111,739,242 Size: 12,275 Coding Exon Count: 2

Page Index	Sequence and Links	UniProtKB Comments	Primers	RNA-Seq Expression	Microarray Expression
RNA Structure	Protein Structure	Other Species	GO Annotations	mRNA Descriptions	Other Names
Methods

Data last updated at UCSC: 2025-09-17 13:57:07

Sequence and Links to Tools and Databases

Genomic Sequence (chr1:111,722,064-111,739,395)			mRNA (may differ from genome)		Protein (297 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Table Schema	AlphaFold	BioGPS
Ensembl	Entrez Gene	ExonPrimer	Gencode	GeneCards	MGI
PubMed	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: F212B_HUMAN DESCRIPTION: RecName: Full=Protein FAM212B; SIMILARITY: Belongs to the FAM212 family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 10.79 RPKM in Whole Blood Total median expression: 125.64 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-80.40	153	-0.525	Picture	PostScript	Text
3' UTR	-1791.20	4904	-0.365	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR026761 - Fam212b

ModBase Predicted Comparative 3D Structure on Q9NTI7


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
Genome Browser	Genome Browser	Genome Browser	No ortholog	No ortholog	No ortholog
Gene Details
Gene Sorter
MGI	RGD	Ensembl
Protein Sequence	Protein Sequence	Protein Sequence
Alignment	Alignment	Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0019901 protein kinase binding GO:0030291 protein serine/threonine kinase inhibitor activity Biological Process: GO:0071901 negative regulation of protein serine/threonine kinase activity Cellular Component: GO:0005634 nucleus

Descriptions from all associated GenBank mRNAs


	AK094997 - Homo sapiens cDNA FLJ37678 fis, clone BRHIP2012750. AK295012 - Homo sapiens cDNA FLJ52261 complete cds. JD021845 - Sequence 2869 from Patent EP1572962. JD032729 - Sequence 13753 from Patent EP1572962. AK092074 - Homo sapiens cDNA FLJ34755 fis, clone NHNPC1000034. JD393881 - Sequence 374905 from Patent EP1572962. JD546650 - Sequence 527674 from Patent EP1572962. JD155369 - Sequence 136393 from Patent EP1572962. JD381816 - Sequence 362840 from Patent EP1572962. JD469261 - Sequence 450285 from Patent EP1572962. JD359255 - Sequence 340279 from Patent EP1572962. JD038433 - Sequence 19457 from Patent EP1572962. JD370047 - Sequence 351071 from Patent EP1572962. JD320581 - Sequence 301605 from Patent EP1572962. JD089436 - Sequence 70460 from Patent EP1572962. JD343875 - Sequence 324899 from Patent EP1572962. JD446693 - Sequence 427717 from Patent EP1572962. JD404023 - Sequence 385047 from Patent EP1572962. JD058485 - Sequence 39509 from Patent EP1572962. JD496080 - Sequence 477104 from Patent EP1572962. JD205685 - Sequence 186709 from Patent EP1572962. JD222565 - Sequence 203589 from Patent EP1572962. JD545238 - Sequence 526262 from Patent EP1572962. JD191192 - Sequence 172216 from Patent EP1572962. JD062653 - Sequence 43677 from Patent EP1572962. JD361126 - Sequence 342150 from Patent EP1572962. JD442191 - Sequence 423215 from Patent EP1572962. JD215731 - Sequence 196755 from Patent EP1572962. JD206873 - Sequence 187897 from Patent EP1572962. JD039049 - Sequence 20073 from Patent EP1572962. JD115970 - Sequence 96994 from Patent EP1572962. JD074244 - Sequence 55268 from Patent EP1572962. JD507516 - Sequence 488540 from Patent EP1572962. JD415435 - Sequence 396459 from Patent EP1572962. JD126987 - Sequence 108011 from Patent EP1572962. JD482875 - Sequence 463899 from Patent EP1572962. JD118415 - Sequence 99439 from Patent EP1572962. JD086932 - Sequence 67956 from Patent EP1572962. JD051498 - Sequence 32522 from Patent EP1572962. JD214539 - Sequence 195563 from Patent EP1572962. AK055667 - Homo sapiens cDNA FLJ31105 fis, clone IMR322000121. JD105787 - Sequence 86811 from Patent EP1572962. JD517388 - Sequence 498412 from Patent EP1572962. JD105786 - Sequence 86810 from Patent EP1572962. JD185302 - Sequence 166326 from Patent EP1572962. JD395363 - Sequence 376387 from Patent EP1572962. JD125545 - Sequence 106569 from Patent EP1572962. JD135613 - Sequence 116637 from Patent EP1572962. JD534616 - Sequence 515640 from Patent EP1572962. JD318218 - Sequence 299242 from Patent EP1572962. AL137198 - Novel human gene mapping to chomosome 1. BC031558 - Homo sapiens chromosome 1 open reading frame 183, mRNA (cDNA clone MGC:34271 IMAGE:5181834), complete cds. AL137199 - Novel human gene mapping to chomosome 1. AK293989 - Homo sapiens cDNA FLJ51810 complete cds. JD120433 - Sequence 101457 from Patent EP1572962. JD178169 - Sequence 159193 from Patent EP1572962. JD242374 - Sequence 223398 from Patent EP1572962. JD495328 - Sequence 476352 from Patent EP1572962. JD043949 - Sequence 24973 from Patent EP1572962. JD485672 - Sequence 466696 from Patent EP1572962. JD561018 - Sequence 542042 from Patent EP1572962. JD216637 - Sequence 197661 from Patent EP1572962. JD466427 - Sequence 447451 from Patent EP1572962. JD544878 - Sequence 525902 from Patent EP1572962. JD244349 - Sequence 225373 from Patent EP1572962. HQ447172 - Synthetic construct Homo sapiens clone IMAGE:100070461; CCSB008442_01 chromosome 1 open reading frame 183 (C1orf183) gene, encodes complete protein. KJ899218 - Synthetic construct Homo sapiens clone ccsbBroadEn_08612 FAM212B gene, encodes complete protein. AB528568 - Synthetic construct DNA, clone: pF1KB9290, Homo sapiens C1orf183 gene for chromosome 1 open reading frame 183, without stop codon, in Flexi system. CU689180 - Synthetic construct Homo sapiens gateway clone IMAGE:100016997 5' read C1orf183 mRNA. JD055319 - Sequence 36343 from Patent EP1572962. JD476351 - Sequence 457375 from Patent EP1572962. JD219119 - Sequence 200143 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: B3KP38, B4DF94, C1orf183 , ENST00000357260.1, ENST00000357260.2, ENST00000357260.3, ENST00000357260.4, ENST00000357260.5, FAM212B, INKA2 , INKA2_HUMAN, NM_198926, Q9NTI6, Q9NTI7, uc001ebo.1, uc001ebo.2, uc001ebo.3 UCSC ID: ENST00000357260.6 RefSeq Accession: NM_019099.5 Protein: Q9NTI7 (aka F212B_HUMAN) CCDS: CCDS841.1

Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.

GNF Expression Atlas 2 Data from U133A and GNF1H Chips