Human Gene TTF2 (ENST00000369466.9) from GENCODE V44
Description: Homo sapiens transcription termination factor 2 (TTF2), mRNA. (from RefSeq NM_003594) RefSeq Summary (NM_003594): This gene encodes a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. The encoded protein has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000369466.9 Gencode Gene: ENSG00000116830.12 Transcript (Including UTRs) Position: hg38 chr1:117,060,326-117,107,453 Size: 47,128 Total Exon Count: 23 Strand: + Coding Region Position: hg38 chr1:117,060,347-117,101,524 Size: 41,178 Coding Exon Count: 23
ID:TTF2_HUMAN DESCRIPTION: RecName: Full=Transcription termination factor 2; EC=3.6.4.-; AltName: Full=Lodestar homolog; AltName: Full=RNA polymerase II termination factor; AltName: Full=Transcription release factor 2; Short=F2; Short=HuF2; FUNCTION: DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing. SUBUNIT: Interacts with CDC5L. Part of the spliceosome. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Cytoplasmic during interphase. Relocates to the nucleus as cells enter mitosis. SIMILARITY: Belongs to the SNF2/RAD54 helicase family. SIMILARITY: Contains 1 helicase ATP-binding domain. SIMILARITY: Contains 1 helicase C-terminal domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UNY4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
