Human Gene ENSA (ENST00000361631.9) from GENCODE V44
Description: Homo sapiens endosulfine alpha (ENSA), transcript variant 5, mRNA. (from RefSeq NM_207045) RefSeq Summary (NM_207045): The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000361631.9 Gencode Gene: ENSG00000143420.19 Transcript (Including UTRs) Position: hg38 chr1:150,622,544-150,629,128 Size: 6,585 Total Exon Count: 5 Strand: - Coding Region Position: hg38 chr1:150,622,844-150,629,105 Size: 6,262 Coding Exon Count: 5
ID:ENSA_HUMAN DESCRIPTION: RecName: Full=Alpha-endosulfine; AltName: Full=ARPP-19e; FUNCTION: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents. SUBUNIT: Interacts (when phosphorylated at Ser-67) with PPP2R2D (By similarity). Interacts with ABCC8. Interacts with SNCA; interaction is disrupted when phosphorylated at Ser-109. INTERACTION: P25205:MCM3; NbExp=1; IntAct=EBI-714511, EBI-355153; SUBCELLULAR LOCATION: Cytoplasm (By similarity). TISSUE SPECIFICITY: Widely expressed with high levels in skeletal muscle and brain and lower levels in the pancreas. PTM: Phosphorylation at Ser-67 by GWL during mitosis is essential for interaction with PPP2R2D (PR55-delta) and subsequent inactivation of PP2A (By similarity). Phosphorylated by PKA. SIMILARITY: Belongs to the endosulfine family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF04667 - cAMP-regulated phosphoprotein/endosulfine conserved region
ModBase Predicted Comparative 3D Structure on O43768
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
