Human Gene C1orf56 (ENST00000368926.6) from GENCODE V44
Description: Homo sapiens chromosome 1 open reading frame 56 (C1orf56), mRNA. (from RefSeq NM_017860) RefSeq Summary (NM_017860): This gene is a proto-oncogene whose promoter is methylated by DNA methyltransferase 3B (DNMT3B), which represses the proto-oncogene. However, a catalytically inactive isoform of DNMT3B is overexpressed in lymphomas, leading to hypomethylation of the proto-oncogene's promoter and derepression of the proto-oncogene. [provided by RefSeq, Sep 2016]. Gencode Transcript: ENST00000368926.6 Gencode Gene: ENSG00000143443.10 Transcript (Including UTRs) Position: hg38 chr1:151,047,751-151,051,420 Size: 3,670 Total Exon Count: 2 Strand: + Coding Region Position: hg38 chr1:151,047,848-151,050,458 Size: 2,611 Coding Exon Count: 2
ID:MENT_HUMAN DESCRIPTION: RecName: Full=Protein MENT; AltName: Full=Methylated in normal thymocytes protein; Flags: Precursor; FUNCTION: Involved in control of cellular proliferation. Onconcogenic modifier contributing to the tumor suppressor function of DNMT3B. SUBCELLULAR LOCATION: Secreted (Potential). TISSUE SPECIFICITY: Plasma. Overexpressed in lymphomas. PTM: Phosphorylation sites are present in the extracellular medium.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
ModBase Predicted Comparative 3D Structure on Q9BUN1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.