Human Gene NTRK1 (ENST00000368196.7) from GENCODE V44
Description: Homo sapiens neurotrophic receptor tyrosine kinase 1 (NTRK1), transcript variant 1, mRNA. (from RefSeq NM_001012331) RefSeq Summary (NM_001012331): This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, cognitive disability and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000368196.7 Gencode Gene: ENSG00000198400.14 Transcript (Including UTRs) Position: hg38 chr1:156,860,815-156,881,850 Size: 21,036 Total Exon Count: 16 Strand: + Coding Region Position: hg38 chr1:156,860,935-156,881,642 Size: 20,708 Coding Exon Count: 16
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK126428 - Homo sapiens cDNA FLJ44464 fis, clone UTERU2025025, highly similar to High affinity nerve growth factor receptor precursor (EC 2.7.1.112). CR936794 - Homo sapiens mRNA; cDNA DKFZp781I14186 (from clone DKFZp781I14186). M23102 - Human trk proto-oncogene insert of pLM6. BC144239 - Homo sapiens neurotrophic tyrosine kinase, receptor, type 1, mRNA (cDNA clone MGC:177776 IMAGE:9052759), complete cds. BC136554 - Homo sapiens neurotrophic tyrosine kinase, receptor, type 1, mRNA (cDNA clone MGC:168167 IMAGE:9020544), complete cds. AK312704 - Homo sapiens cDNA, FLJ93103, Homo sapiens neurotrophic tyrosine kinase, receptor, type 1(NTRK1), mRNA. AK290759 - Homo sapiens cDNA FLJ75372 complete cds, highly similar to Human trk proto-oncogene insert of pLM6. KJ534902 - Homo sapiens clone NTRK1_iso-A_adult-A14 neurotrophic tyrosine kinase receptor type 1 isoform A (NTRK1) mRNA, partial cds, alternatively spliced. KJ534903 - Homo sapiens clone NTRK1_iso-B_fetal-F12 neurotrophic tyrosine kinase receptor type 1 isoform B (NTRK1) mRNA, partial cds, alternatively spliced. BC062580 - Homo sapiens neurotrophic tyrosine kinase, receptor, type 1, mRNA (cDNA clone IMAGE:5200930), partial cds. KF724385 - Homo sapiens MHC class II invariant chain/neurotrophic tyrosine kinase receptor type 1 fusion protein (CD74-NTRK1 fusion) mRNA, complete cds. X85960 - H.sapiens TRK-T3 oncogene. X03541 - Human mRNA of trk oncogene. X06704 - Human mRNA for trk-2h oncogene. M55337 - Human oncogene tyrosine protein kinase receptor (trk4) mRNA, partial cds. M55336 - Homo sapiens oncogene tyrosine protein kinase receptor (trk2) mRNA, partial cds. X62947 - H.sapiens mRNA (TRK-T1) for 55 KD protein.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04010 - MAPK signaling pathway hsa04144 - Endocytosis hsa04210 - Apoptosis hsa04722 - Neurotrophin signaling pathway hsa05200 - Pathways in cancer hsa05216 - Thyroid cancer
BioCarta from NCI Cancer Genome Anatomy Project h_erk5Pathway - Role of Erk5 in Neuronal Survival h_actinYPathway - Y branching of actin filaments h_trkaPathway - Trka Receptor Signaling Pathway
GeneReviews article(s) related to gene NTRK1: cip-overview (Congenital Insensitivity to Pain Overview) hsan4 (NTRK1 Congenital Insensitivity to Pain with Anhidrosis)
Methods, Credits, and Use Restrictions
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