Human Gene KIRREL1 (ENST00000368172.2) from GENCODE V44
Description: kirre like nephrin family adhesion molecule 1 (from HGNC KIRREL1) RefSeq Summary (NM_018240): NEPH1 is a member of the nephrin-like protein family, which includes NEPH2 (MIM 607761) and NEPH3 (MIM 607762). The cytoplasmic domains of these proteins interact with the C terminus of podocin (NPHS2; MIM 604766), and the genes are expressed in kidney podocytes, cells involved in ensuring size- and charge-selective ultrafiltration (Sellin et al., 2003 [PubMed 12424224]).[supplied by OMIM, Mar 2008]. Gencode Transcript: ENST00000368172.2 Gencode Gene: ENSG00000183853.18 Transcript (Including UTRs) Position: hg38 chr1:158,084,422-158,100,262 Size: 15,841 Total Exon Count: 12 Strand: + Coding Region Position: hg38 chr1:158,084,422-158,095,120 Size: 10,699 Coding Exon Count: 12
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q5W0G0
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.