Human Gene KLHDC9 (ENST00000368011.9) from GENCODE V44
  Description: Homo sapiens kelch domain containing 9 (KLHDC9), transcript variant 1, mRNA. (from RefSeq NM_152366)
Gencode Transcript: ENST00000368011.9
Gencode Gene: ENSG00000162755.14
Transcript (Including UTRs)
   Position: hg38 chr1:161,098,361-161,100,346 Size: 1,986 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg38 chr1:161,098,536-161,100,224 Size: 1,689 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:161,098,361-161,100,346)mRNA (may differ from genome)Protein (349 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: KLDC9_HUMAN
DESCRIPTION: RecName: Full=Kelch domain-containing protein 9; AltName: Full=Kelch/ankyrin repeat-containing cyclin A1-interacting protein;
SUBUNIT: Interacts with CCNA1.
SIMILARITY: Contains 3 Kelch repeats.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 74.45 RPKM in Testis
Total median expression: 346.70 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -85.30175-0.487 Picture PostScript Text
3' UTR -18.40122-0.151 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011043 - Gal_Oxase/kelch_b-propeller
IPR015915 - Kelch-typ_b-propeller

ModBase Predicted Comparative 3D Structure on Q8NEP7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0030332 cyclin binding

Biological Process:
GO:0008150 biological_process

Cellular Component:
GO:0005575 cellular_component


-  Descriptions from all associated GenBank mRNAs
  BC032482 - Homo sapiens kelch domain containing 9, mRNA (cDNA clone MGC:40607 IMAGE:5222141), complete cds.
JD439045 - Sequence 420069 from Patent EP1572962.
AY601914 - Homo sapiens kelch/ankyrin repeat containing cyclin A1 interacting protein (KARCA1) mRNA, complete cds.
BC022077 - Homo sapiens kelch domain containing 9, mRNA (cDNA clone MGC:33338 IMAGE:4822843), complete cds.
BC066896 - Homo sapiens kelch domain containing 9, mRNA (cDNA clone MGC:86989 IMAGE:4828667), complete cds.
AK093268 - Homo sapiens cDNA FLJ35949 fis, clone TESTI2012050.
AX748022 - Sequence 1547 from Patent EP1308459.
JD036898 - Sequence 17922 from Patent EP1572962.
JD469087 - Sequence 450111 from Patent EP1572962.
JD477959 - Sequence 458983 from Patent EP1572962.
JD056214 - Sequence 37238 from Patent EP1572962.
KJ906416 - Synthetic construct Homo sapiens clone ccsbBroadEn_16086 KLHDC9 gene, encodes complete protein.
HQ448491 - Synthetic construct Homo sapiens clone IMAGE:100071923; CCSB011007_01 kelch/ankyrin repeat containing cyclin A1 interacting protein (KLHDC9) gene, encodes complete protein.
KJ900109 - Synthetic construct Homo sapiens clone ccsbBroadEn_09503 KLHDC9 gene, encodes complete protein.
JD298045 - Sequence 279069 from Patent EP1572962.
JD200112 - Sequence 181136 from Patent EP1572962.
JD515504 - Sequence 496528 from Patent EP1572962.
JD538137 - Sequence 519161 from Patent EP1572962.
JD384530 - Sequence 365554 from Patent EP1572962.
JD529035 - Sequence 510059 from Patent EP1572962.
JD040850 - Sequence 21874 from Patent EP1572962.
JD267978 - Sequence 249002 from Patent EP1572962.
KJ903727 - Synthetic construct Homo sapiens clone ccsbBroadEn_13121 KLHDC9 gene, encodes complete protein.
JD444095 - Sequence 425119 from Patent EP1572962.
DQ577846 - Homo sapiens piRNA piR-45958, complete sequence.
JD250892 - Sequence 231916 from Patent EP1572962.
JD285951 - Sequence 266975 from Patent EP1572962.
JD449779 - Sequence 430803 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000368011.1, ENST00000368011.2, ENST00000368011.3, ENST00000368011.4, ENST00000368011.5, ENST00000368011.6, ENST00000368011.7, ENST00000368011.8, KARCA1, KLDC9_HUMAN, NM_152366, Q5SY56, Q6NXT9, Q6PKN4, Q8N5E1, Q8NA16, Q8NEP7, uc001fxr.1, uc001fxr.2, uc001fxr.3, uc001fxr.4, uc001fxr.5
UCSC ID: ENST00000368011.9
RefSeq Accession: NM_152366
Protein: Q8NEP7 (aka KLDC9_HUMAN)
CCDS: CCDS30919.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.