Human Gene FMO4 (ENST00000367749.4) from GENCODE V44
Description: Homo sapiens flavin containing dimethylaniline monoxygenase 4 (FMO4), mRNA. (from RefSeq NM_002022) RefSeq Summary (NM_002022): Metabolic N-oxidation of diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man. This results in a small subpopulation with reduced TMA N-oxidation capacity and causes fish odor syndrome (Trimethylaminuria). Three forms of the enzyme are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. [provided by RefSeq, Jan 2015]. Gencode Transcript: ENST00000367749.4 Gencode Gene: ENSG00000076258.10 Transcript (Including UTRs) Position: hg38 chr1:171,314,183-171,342,084 Size: 27,902 Total Exon Count: 10 Strand: + Coding Region Position: hg38 chr1:171,319,826-171,341,839 Size: 22,014 Coding Exon Count: 8
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P31512
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
