ID:NS1BP_HUMAN DESCRIPTION: RecName: Full=Influenza virus NS1A-binding protein; Short=NS1-BP; Short=NS1-binding protein; AltName: Full=Aryl hydrocarbon receptor-associated protein 3; FUNCTION: Plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization; Protects neurons from dendritic spines and actin filaments damage induced by the actin-destabilizing cytochalasin B when overexpressed. Activates Erk signaling pathway when overexpressed in cultured cell lines (By similarity). May be a component of the cellular splicing machinery with a role in pre-mRNA splicing; may mediate the inhibition of splicing by NS/influenza virus NS1A protein. Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription. SUBUNIT: Homodimer; through the BTB domain (By similarity). Interacts with NS/Influenza virus NS1A protein and with AHR/Aryl hydrocarbon receptor. SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton. Nucleus, nucleoplasm. Note=Associated with actin filaments (By similarity). Localization related to speckle domains which correspond to interchromatin granules and are enriched in factors involved in pre-mRNA splicing. Following influenza A virus infection, redistribution from speckles to a more diffuse distribution in the nucleoplasm. DOMAIN: When the BTB domain is lacking, AHR signaling induction promoted by IVNS1ABP is massively increased; Thus, the BTB domain inhibits AHR signaling induced by IVNS1ABP. SIMILARITY: Contains 1 BACK (BTB/Kelch associated) domain. SIMILARITY: Contains 1 BTB (POZ) domain. SIMILARITY: Contains 6 Kelch repeats. SEQUENCE CAUTION: Sequence=AAF29040.1; Type=Frameshift; Positions=100, 102; Sequence=BAA74873.2; Type=Erroneous initiation; Sequence=CAA10029.1; Type=Frameshift; Positions=612; Sequence=CAI17867.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y6Y0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006383 transcription from RNA polymerase III promoter GO:0008380 RNA splicing GO:0009615 response to virus GO:0016032 viral process GO:0031397 negative regulation of protein ubiquitination GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
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