ID:AIDA_HUMAN DESCRIPTION: RecName: Full=Axin interactor, dorsalization-associated protein; AltName: Full=Axin interaction partner and dorsalization antagonist; FUNCTION: Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity). SUBUNIT: Interacts with AXIN1 (By similarity). TISSUE SPECIFICITY: Widely expressed in adult tissues, with highest expression in the heart and skeletal muscle. SIMILARITY: Belongs to the AIDA family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96BJ3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0019904 protein domain specific binding GO:0035091 phosphatidylinositol binding
Biological Process: GO:0007275 multicellular organism development GO:0009953 dorsal/ventral pattern formation GO:0043496 regulation of protein homodimerization activity GO:0043508 negative regulation of JUN kinase activity GO:0046329 negative regulation of JNK cascade GO:0048264 determination of ventral identity
US Server
