Human Gene CAPN9 (ENST00000354537.1) from GENCODE V44
Description: Homo sapiens calpain 9 (CAPN9), transcript variant 2, mRNA. (from RefSeq NM_016452) RefSeq Summary (NM_006615): Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is expressed predominantly in stomach and small intestine and may have specialized functions in the digestive tract. This gene is thought to be associated with gastric cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000354537.1 Gencode Gene: ENSG00000135773.13 Transcript (Including UTRs) Position: hg38 chr1:230,747,415-230,802,003 Size: 54,589 Total Exon Count: 19 Strand: + Coding Region Position: hg38 chr1:230,747,497-230,801,596 Size: 54,100 Coding Exon Count: 19
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O14815
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
