Human Gene BMI1 (ENST00000376663.8) from GENCODE V44
Description: Homo sapiens BMI1 proto-oncogene, polycomb ring finger (BMI1), mRNA. (from RefSeq NM_005180) RefSeq Summary (NM_005180): This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene. [provided by RefSeq, Sep 2015]. Gencode Transcript: ENST00000376663.8 Gencode Gene: ENSG00000168283.14 Transcript (Including UTRs) Position: hg38 chr10:22,321,099-22,331,484 Size: 10,386 Total Exon Count: 10 Strand: + Coding Region Position: hg38 chr10:22,326,450-22,329,542 Size: 3,093 Coding Exon Count: 9
ID:BMI1_HUMAN DESCRIPTION: RecName: Full=Polycomb complex protein BMI-1; AltName: Full=Polycomb group RING finger protein 4; AltName: Full=RING finger protein 51; FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2. SUBUNIT: Component of a PRC1-like complex. Interacts with RING1 and RING2 (By similarity). Interacts vwith CBX7 and CBX8. Interacts with SPOP. Part of a complex consisting of BMI1, CUL3 and SPOP. Interacts with E4F1. INTERACTION: O00257-3:CBX4; NbExp=2; IntAct=EBI-2341576, EBI-4392727; O95503:CBX6; NbExp=2; IntAct=EBI-2341576, EBI-3951758; O95931:CBX7; NbExp=5; IntAct=EBI-2341576, EBI-3923843; Q9HC52:CBX8; NbExp=6; IntAct=EBI-2341576, EBI-712912; Q06587:RING1; NbExp=5; IntAct=EBI-2341576, EBI-752313; Q99496:RNF2; NbExp=5; IntAct=EBI-2341576, EBI-722416; Q9H270:VPS11; NbExp=2; IntAct=EBI-2341576, EBI-373380; SUBCELLULAR LOCATION: Nucleus. Cytoplasm. PTM: Monoubiquitinated (By similarity). May be polyubiquitinated; which does not lead to proteasomal degradation. MISCELLANEOUS: The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of different PRC1-like complexes. SIMILARITY: Contains 1 RING-type zinc finger.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P35226
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
