Human Gene MPP7 (ENST00000375719.7) from GENCODE V44
Description: Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact. (from UniProt Q5T2T1) RefSeq Summary (NM_173496): The protein encoded by this gene is a member of the p55 Stardust family of membrane-associated guanylate kinase (MAGUK) proteins, which function in the establishment of epithelial cell polarity. This family member forms a complex with the polarity protein DLG1 (discs, large homolog 1) and facilitates epithelial cell polarity and tight junction formation. Polymorphisms in this gene are associated with variations in site-specific bone mineral density (BMD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]. Gencode Transcript: ENST00000375719.7 Gencode Gene: ENSG00000150054.19 Transcript (Including UTRs) Position: hg38 chr10:28,054,061-28,282,089 Size: 228,029 Total Exon Count: 19 Strand: - Coding Region Position: hg38 chr10:28,054,065-28,238,604 Size: 184,540 Coding Exon Count: 16
ID:MPP7_HUMAN DESCRIPTION: RecName: Full=MAGUK p55 subfamily member 7; FUNCTION: Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact. SUBUNIT: Heterodimer; able to heterodimerize via its C-terminal L27 domain with LIN7A, LIN7B and LIN7C. Forms a tripartite complex composed of DLG1, MPP7 and LIN7 (LIN7A or LIN7C). Interacts with DLG1 via its N-terminal L27 domain. Interacts with MPP5 and INADL/PATJ. SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein. Cell junction, tight junction. Cell junction, adherens junction. INDUCTION: Down-regulated in patients suffering of passive Heymann nephritis (at protein level). SIMILARITY: Belongs to the MAGUK family. SIMILARITY: Contains 1 guanylate kinase-like domain. SIMILARITY: Contains 2 L27 domains. SIMILARITY: Contains 1 PDZ (DHR) domain. SIMILARITY: Contains 1 SH3 domain. SEQUENCE CAUTION: Sequence=CAI12709.1; Type=Erroneous gene model prediction; Sequence=CAI13640.1; Type=Erroneous gene model prediction; Sequence=CAI17344.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q5T2T1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0009967 positive regulation of signal transduction GO:0030010 establishment of cell polarity GO:0031334 positive regulation of protein complex assembly GO:0070830 bicellular tight junction assembly GO:0071896 protein localization to adherens junction
US Server
