ID:RGF1A_HUMAN DESCRIPTION: RecName: Full=Ras-GEF domain-containing family member 1A; FUNCTION: Guanine nucleotide exchange factor (GEF) with specificity for RAP2A, KRAS, HRAS, and NRAS (in vitro). Plays a role in cell migration. TISSUE SPECIFICITY: Detected in brain and spinal cord. Highly expressed in a number of intrahepatic cholangiocarcinoma tissue biopsies. SIMILARITY: Contains 1 N-terminal Ras-GEF domain. SIMILARITY: Contains 1 Ras-GEF domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8N9B8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000165 MAPK cascade GO:0007264 small GTPase mediated signal transduction GO:0016477 cell migration GO:0046579 positive regulation of Ras protein signal transduction