Human Gene MAPK8 (ENST00000395611.7) from GENCODE V44
  Description: Homo sapiens mitogen-activated protein kinase 8 (MAPK8), transcript variant 20, non-coding RNA. (from RefSeq NR_136585)
RefSeq Summary (NM_001278547): The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016].
Gencode Transcript: ENST00000395611.7
Gencode Gene: ENSG00000107643.17
Transcript (Including UTRs)
   Position: hg38 chr10:48,306,639-48,439,357 Size: 132,719 Total Exon Count: 12 Strand: +
Coding Region
   Position: hg38 chr10:48,401,661-48,435,029 Size: 33,369 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:48,306,639-48,439,357)mRNA (may differ from genome)Protein (427 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCLynxMalacardsMGIneXtProtOMIM
PubMedReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: MK08_HUMAN
DESCRIPTION: RecName: Full=Mitogen-activated protein kinase 8; Short=MAP kinase 8; Short=MAPK 8; EC=2.7.11.24; AltName: Full=JNK-46; AltName: Full=Stress-activated protein kinase 1c; Short=SAPK1c; AltName: Full=Stress-activated protein kinase JNK1; AltName: Full=c-Jun N-terminal kinase 1;
FUNCTION: Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins. Loss of this interaction abrogates the acetylation required for replication initiation. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including p53/TP53 and Yes-associates protein YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Contributes to the survival of erythroid cells by phosphorylating the antagonist of cell death BAD upon EPO stimulation. Mediates starvation-induced BCL2 phosphorylation, BCL2 dissociation from BECN1, and thus activation of autophagy. Phosphorylates STMN2 and hence regulates microtubule dynamics, controlling neurite elongation in cortical neurons. In the developing brain, through its cytoplasmic activity on STMN2, negatively regulates the rate of exit from multipolar stage and of radial migration from the ventricular zone. Phosphorylates several other substrates including heat shock factor protein 4 (HSF4), the deacetylase SIRT1, ELK1, or the E3 ligase ITCH.
FUNCTION: JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta- 2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms.
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
COFACTOR: Magnesium.
ENZYME REGULATION: Activated by threonine and tyrosine phosphorylation by either of two dual specificity kinases, MAP2K4 and MAP2K7. MAP2K4 shows a strong preference for Tyr-185 while MAP2K7 phosphorylates Tyr-183 preferentially. Inhibited by dual specificity phosphatases, such as DUSP1.
SUBUNIT: Binds to at least four scaffolding proteins, MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK8IP3/JIP-3/JSAP1 and SPAG9/MAPK8IP4/JIP-4. These proteins also bind other components of the JNK signaling pathway. Interacts with TP53 and WWOX. Interacts with JAMP. Forms a complex with MAPK8IP1 and ARHGEF28 (By similarity). Interacts (phosphorylated form) with NFE2; the interaction phosphorylates NFE2 in undifferentiated cells (By similarity). Interacts with NFATC4. Interacts with MECOM; regulates JNK signaling. Interacts with PIN1; this interaction mediates MAPK8 conformational changes leading to the binding of MAPK8 to its substrates.
INTERACTION: P05412:JUN; NbExp=2; IntAct=EBI-286483, EBI-852823; O14733-2:MAP2K7; NbExp=3; IntAct=EBI-286483, EBI-492627; Q9WVI9-1:Mapk8ip1 (xeno); NbExp=2; IntAct=EBI-286483, EBI-288461;
SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
DOMAIN: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
PTM: Dually phosphorylated on Thr-183 and Tyr-185 by MAP2K7 and MAP2K4, which activates the enzyme. Phosphorylated by TAOK2.
SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
SIMILARITY: Contains 1 protein kinase domain.
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/JNK1ID196.html";
WEB RESOURCE: Name=Wikipedia; Note=C-Jun N-terminal kinases entry; URL="http://en.wikipedia.org/wiki/C-Jun_N-terminal_kinases";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: MAPK8
Diseases sorted by gene-association score: fatty liver disease (10), renal fibrosis (7), myasthenic syndrome, congenital, 9, associated with acetylcholine receptor deficiency (6), epidermolysis bullosa simplex, dowling-meara type (6), hepatocellular carcinoma (6), breast cancer (6), small intestine neuroendocrine neoplasm (6), hepatitis (5), bile duct carcinoma (5), hepatitis c (5), atherosclerosis (5), pancreatic cancer (4), toxic myocarditis (4), colorectal cancer (4), lung cancer (4), cardiomyopathy, hypertrophic, 2 (4), enterobiasis (4), carbuncle (3), vaccinia (3), prostate cancer (2), nasopharyngeal carcinoma (2), leukemia, acute promyelocytic, somatic (2), ovarian cancer, somatic (1), parkinson disease, late-onset (1), toxic encephalopathy (1), osteosarcoma, somatic (1), diabetes mellitus, noninsulin-dependent (1), leukemia, acute myeloid (0)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 12.75 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 239.58 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -107.70232-0.464 Picture PostScript Text
3' UTR -1023.704328-0.237 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011009 - Kinase-like_dom
IPR003527 - MAP_kinase_CS
IPR008351 - MAPK_JNK
IPR000719 - Prot_kinase_cat_dom
IPR002290 - Ser/Thr_dual-sp_kinase_dom
IPR008271 - Ser/Thr_kinase_AS

Pfam Domains:
PF00069 - Protein kinase domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1UKH - X-ray MuPIT 1UKI - X-ray MuPIT 2G01 - X-ray MuPIT 2GMX - X-ray MuPIT 2H96 - X-ray MuPIT 2NO3 - X-ray MuPIT 2XRW - X-ray MuPIT 2XS0 - X-ray MuPIT 3ELJ - X-ray MuPIT 3O17 - X-ray MuPIT 3O2M - X-ray MuPIT 3PZE - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P45983
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004705 JUN kinase activity
GO:0004707 MAP kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0019899 enzyme binding
GO:0035033 histone deacetylase regulator activity
GO:0042826 histone deacetylase binding

Biological Process:
GO:0006468 protein phosphorylation
GO:0007254 JNK cascade
GO:0007258 JUN phosphorylation
GO:0009411 response to UV
GO:0010628 positive regulation of gene expression
GO:0016241 regulation of macroautophagy
GO:0016310 phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0031063 regulation of histone deacetylation
GO:0031281 positive regulation of cyclase activity
GO:0032091 negative regulation of protein binding
GO:0032880 regulation of protein localization
GO:0034198 cellular response to amino acid starvation
GO:0034614 cellular response to reactive oxygen species
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042752 regulation of circadian rhythm
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0048511 rhythmic process
GO:0048666 neuron development
GO:0051247 positive regulation of protein metabolic process
GO:0051403 stress-activated MAPK cascade
GO:0071222 cellular response to lipopolysaccharide
GO:0071260 cellular response to mechanical stimulus
GO:0071276 cellular response to cadmium ion
GO:0071345 cellular response to cytokine stimulus
GO:0090045 positive regulation of deacetylase activity
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1902595 regulation of DNA replication origin binding

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0030424 axon
GO:0043005 neuron projection
GO:0097441 basilar dendrite


-  Descriptions from all associated GenBank mRNAs
  AK292523 - Homo sapiens cDNA FLJ77387 complete cds, highly similar to Homo sapiens mitogen-activated protein kinase 8 (MAPK8), transcript variant 4, mRNA.
BC130570 - Homo sapiens mitogen-activated protein kinase 8, mRNA (cDNA clone MGC:163442 IMAGE:40146601), complete cds.
BC130572 - Homo sapiens mitogen-activated protein kinase 8, mRNA (cDNA clone MGC:163444 IMAGE:40146603), complete cds.
BC144063 - Homo sapiens mitogen-activated protein kinase 8, mRNA (cDNA clone MGC:177600 IMAGE:9052583), complete cds.
U35004 - Human JNK1 beta1 protein kinase (JNK1B1) mRNA, complete cds.
HH837089 - Sequence 16 from Patent EP2231168.
HH837090 - Sequence 17 from Patent EP2231168.
HH837091 - Sequence 18 from Patent EP2231168.
HH837092 - Sequence 19 from Patent EP2231168.
HI214730 - Sequence 16 from Patent EP2076526.
HI214731 - Sequence 17 from Patent EP2076526.
HI214732 - Sequence 18 from Patent EP2076526.
HI214733 - Sequence 19 from Patent EP2076526.
HV601532 - JP 2011500003-A/16: Novel siRNA Structures.
HV601533 - JP 2011500003-A/17: Novel siRNA Structures.
HV601534 - JP 2011500003-A/18: Novel siRNA Structures.
HV601535 - JP 2011500003-A/19: Novel siRNA Structures.
HV856605 - JP 2010507387-A/16: Novel siRNAs and Methods of Use Thereof.
HV856606 - JP 2010507387-A/17: Novel siRNAs and Methods of Use Thereof.
HV856607 - JP 2010507387-A/18: Novel siRNAs and Methods of Use Thereof.
HV856608 - JP 2010507387-A/19: Novel siRNAs and Methods of Use Thereof.
HW061143 - JP 2012529430-A/18: METHODS FOR TREATING CHRONIC KIDNEY DISEASE.
HW061144 - JP 2012529430-A/19: METHODS FOR TREATING CHRONIC KIDNEY DISEASE.
HW061145 - JP 2012529430-A/20: METHODS FOR TREATING CHRONIC KIDNEY DISEASE.
HW061146 - JP 2012529430-A/21: METHODS FOR TREATING CHRONIC KIDNEY DISEASE.
HW165092 - JP 2013102767-A/16: Novel siRNA's and Use Thereof.
HW165093 - JP 2013102767-A/17: Novel siRNA's and Use Thereof.
HW165094 - JP 2013102767-A/18: Novel siRNA's and Use Thereof.
HW165095 - JP 2013102767-A/19: Novel siRNA's and Use Thereof.
HW675600 - JP 2014210789-A/16: Novel siRNA Structures.
HW675601 - JP 2014210789-A/17: Novel siRNA Structures.
HW675602 - JP 2014210789-A/18: Novel siRNA Structures.
HW675603 - JP 2014210789-A/19: Novel siRNA Structures.
HW835288 - JP 2015051004-A/16: Novel siRNA's and Use Thereof.
HW835289 - JP 2015051004-A/17: Novel siRNA's and Use Thereof.
HW835290 - JP 2015051004-A/18: Novel siRNA's and Use Thereof.
HW835291 - JP 2015051004-A/19: Novel siRNA's and Use Thereof.
JA482098 - Sequence 81 from Patent WO2011072091.
JA482099 - Sequence 82 from Patent WO2011072091.
JA482100 - Sequence 83 from Patent WO2011072091.
JA482101 - Sequence 84 from Patent WO2011072091.
JA538131 - Sequence 16 from Patent EP2371958.
JA538132 - Sequence 17 from Patent EP2371958.
JA538133 - Sequence 18 from Patent EP2371958.
JA538134 - Sequence 19 from Patent EP2371958.
JB251951 - Sequence 18 from Patent EP2440214.
JB251952 - Sequence 19 from Patent EP2440214.
JB251953 - Sequence 20 from Patent EP2440214.
JB251954 - Sequence 21 from Patent EP2440214.
JE980390 - Sequence 81 from Patent EP2862929.
JE980391 - Sequence 82 from Patent EP2862929.
JE980392 - Sequence 83 from Patent EP2862929.
JE980393 - Sequence 84 from Patent EP2862929.
L26318 - Human protein kinase (JNK1) mRNA, complete cds.
LP764850 - Sequence 18 from Patent EP3276004.
LP764851 - Sequence 19 from Patent EP3276004.
LP764852 - Sequence 20 from Patent EP3276004.
LP764853 - Sequence 21 from Patent EP3276004.
U35005 - Human JNK1 beta2 protein kinase (JNK1B2) mRNA, complete cds.
U34822 - Human JNK1 alpha2 protein kinase (JNK1A2) mRNA, complete cds.
HQ258413 - Synthetic construct Homo sapiens clone IMAGE:100072842 mitogen-activated protein kinase 8 (MAPK8), transcript variant JNK1-b2 (MAPK8) gene, encodes complete protein.
KJ891893 - Synthetic construct Homo sapiens clone ccsbBroadEn_01287 MAPK8 gene, encodes complete protein.
AB527605 - Synthetic construct DNA, clone: pF1KB6687, Homo sapiens MAPK8 gene for mitogen-activated protein kinase 8, without stop codon, in Flexi system.
AB451354 - Homo sapiens MAPK8 mRNA for mitogen-activated protein kinase 8 isoform JNK1 alpha1, partial cds, clone: FLJ08021AAAF.
AB451231 - Homo sapiens MAPK8 mRNA for mitogen-activated protein kinase 8 isoform JNK1 alpha1, complete cds, clone: FLJ08021AAAN.
DQ234352 - Homo sapiens mitogen-activated protein kinase 8 transcript variant 2 mRNA, complete cds, alternatively spliced.
AB451398 - Homo sapiens MAPK8 mRNA for mitogen-activated protein kinase 8 isoform JNK1 beta2, partial cds, clone: FLJ08098AAAF.
AB451271 - Homo sapiens MAPK8 mRNA for mitogen-activated protein kinase 8 isoform JNK1 beta2, complete cds, clone: FLJ08098AAAN.
AL137667 - Homo sapiens mRNA; cDNA DKFZp434B231 (from clone DKFZp434B231).
AK094000 - Homo sapiens cDNA FLJ36681 fis, clone UTERU2006547.
AX748405 - Sequence 1930 from Patent EP1308459.
JD069093 - Sequence 50117 from Patent EP1572962.
JD316726 - Sequence 297750 from Patent EP1572962.
JD267188 - Sequence 248212 from Patent EP1572962.
AK125150 - Homo sapiens cDNA FLJ43160 fis, clone FCBBF2000199.
AB074280 - Homo sapiens primary neuroblastoma cDNA, clone:Nbla11051, full insert sequence.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04010 - MAPK signaling pathway
hsa04012 - ErbB signaling pathway
hsa04310 - Wnt signaling pathway
hsa04510 - Focal adhesion
hsa04620 - Toll-like receptor signaling pathway
hsa04621 - NOD-like receptor signaling pathway
hsa04622 - RIG-I-like receptor signaling pathway
hsa04664 - Fc epsilon RI signaling pathway
hsa04722 - Neurotrophin signaling pathway
hsa04910 - Insulin signaling pathway
hsa04912 - GnRH signaling pathway
hsa04914 - Progesterone-mediated oocyte maturation
hsa04920 - Adipocytokine signaling pathway
hsa04930 - Type II diabetes mellitus
hsa05120 - Epithelial cell signaling in Helicobacter pylori infection
hsa05131 - Shigellosis
hsa05142 - Chagas disease
hsa05200 - Pathways in cancer
hsa05210 - Colorectal cancer
hsa05212 - Pancreatic cancer

BioCarta from NCI Cancer Genome Anatomy Project
h_arenrf2Pathway - Oxidative Stress Induced Gene Expression Via Nrf2
h_dspPathway - Regulation of MAP Kinase Pathways Through Dual Specificity Phosphatases
h_epoPathway - EPO Signaling Pathway
h_il1rPathway - Signal transduction through IL1R
h_insulinPathway - Insulin Signaling Pathway
h_keratinocytePathway - Keratinocyte Differentiation
h_malPathway - Role of MAL in Rho-Mediated Activation of SRF
h_mapkPathway - MAPKinase Signaling Pathway
h_tollPathway - Toll-Like Receptor Pathway
h_IL12Pathway - IL12 and Stat4 Dependent Signaling Pathway in Th1 Development
h_ngfPathway - Nerve growth factor pathway (NGF)
h_pyk2Pathway - Links between Pyk2 and Map Kinases
h_ranklPathway - Bone Remodelling
h_tnfr1Pathway - TNFR1 Signaling Pathway
h_41bbPathway - The 4-1BB-dependent immune response
h_atmPathway - ATM Signaling Pathway
h_egfPathway - EGF Signaling Pathway
h_fasPathway - FAS signaling pathway ( CD95 )
h_tall1Pathway - TACI and BCMA stimulation of B cell immune responses.
h_tcrPathway - T Cell Receptor Signaling Pathway
h_p53hypoxiaPathway - Hypoxia and p53 in the Cardiovascular system
h_agrPathway - Agrin in Postsynaptic Differentiation
h_ceramidePathway - Ceramide Signaling Pathway
h_fcer1Pathway - Fc Epsilon Receptor I Signaling in Mast Cells
h_metPathway - Signaling of Hepatocyte Growth Factor Receptor
h_nfatPathway - NFAT and Hypertrophy of the heart (Transcription in the broken heart)
h_pdgfPathway - PDGF Signaling Pathway
h_At1rPathway - Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling
h_Ccr5Pathway - Pertussis toxin-insensitive CCR5 Signaling in Macrophage
h_bcrPathway - BCR Signaling Pathway
h_il2Pathway - IL 2 signaling pathway
h_stressPathway - TNF/Stress Related Signaling
h_HivnefPathway - HIV-I Nef: negative effector of Fas and TNF
h_biopeptidesPathway - Bioactive Peptide Induced Signaling Pathway
h_gleevecpathway - Inhibition of Cellular Proliferation by Gleevec
h_igf1Pathway - IGF-1 Signaling Pathway
h_integrinPathway - Integrin Signaling Pathway

Reactome (by CSHL, EBI, and GO)

Protein P45983 (Reactome details) participates in the following event(s):

R-HSA-204949 NRIF and TRAF6 may activate JNK
R-HSA-205132 NRAGE activates JNK
R-HSA-205136 GTP-bound RAC contributes to JNK activation
R-HSA-451347 Activation of JNK by DSCAM
R-HSA-193666 Active JNK moves to the nucleus and phosphorylates different transcription factors
R-HSA-5683986 APBB1 and MAPK8 bind diphosphorylated H2AFX
R-HSA-168162 Phosphorylation of human JNKs by activated MKK4/MKK7
R-HSA-139908 Phosphorylation of DLC2 by MAPK8
R-HSA-139918 Phosphorylation of BIM by JNK
R-HSA-450348 Activated human JNKs migrate to nucleoplasm
R-HSA-205075 JNK phosphorylates BIM, BAD and other targets
R-HSA-168136 Activated JNKs phosphorylate c-JUN
R-HSA-168053 Phosphorylated MAPKs phosphorylate ATF-2
R-HSA-205043 NRIF signals cell death from the nucleus
R-HSA-193648 NRAGE signals death through JNK
R-HSA-376172 DSCAM interactions
R-HSA-9007892 Interleukin-38 signaling
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-HSA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
R-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-2871796 FCERI mediated MAPK activation
R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE
R-HSA-373752 Netrin-1 signaling
R-HSA-446652 Interleukin-1 family signaling
R-HSA-139910 Activation of BMF and translocation to mitochondria
R-HSA-111446 Activation of BIM and translocation to mitochondria
R-HSA-5693606 DNA Double Strand Break Response
R-HSA-450294 MAP kinase activation
R-HSA-2559583 Cellular Senescence
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-193704 p75 NTR receptor-mediated signalling
R-HSA-422475 Axon guidance
R-HSA-449147 Signaling by Interleukins
R-HSA-114452 Activation of BH3-only proteins
R-HSA-450341 Activation of the AP-1 family of transcription factors
R-HSA-5693532 DNA Double-Strand Break Repair
R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade
R-HSA-448424 Interleukin-17 signaling
R-HSA-937061 TRIF(TICAM1)-mediated TLR4 signaling
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-HSA-975871 MyD88 cascade initiated on plasma membrane
R-HSA-2262752 Cellular responses to stress
R-HSA-168249 Innate Immune System
R-HSA-73887 Death Receptor Signalling
R-HSA-1266738 Developmental Biology
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-109606 Intrinsic Pathway for Apoptosis
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases
R-HSA-73894 DNA Repair
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade
R-HSA-168898 Toll-Like Receptors Cascades
R-HSA-166166 MyD88-independent TLR4 cascade
R-HSA-975155 MyD88 dependent cascade initiated on endosome
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-168256 Immune System
R-HSA-162582 Signal Transduction
R-HSA-109581 Apoptosis
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
R-HSA-5357801 Programmed Cell Death

-  Other Names for This Gene
  Alternate Gene Symbols: B5BTZ5, B7ZLV4, D3DX88, D3DX92, ENST00000395611.1, ENST00000395611.2, ENST00000395611.3, ENST00000395611.4, ENST00000395611.5, ENST00000395611.6, JNK1, MK08_HUMAN, NR_136585, P45983, PRKM8, Q15709, Q15712, Q15713, SAPK1, SAPK1C, uc001jgn.1, uc001jgn.2, uc001jgn.3, uc001jgn.4, uc001jgn.5
UCSC ID: ENST00000395611.7
RefSeq Accession: NM_001278547
Protein: P45983 (aka MK08_HUMAN)
CCDS: CCDS7223.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.