Human Gene ZNF365 (ENST00000395254.8) from GENCODE V44
Description: Homo sapiens zinc finger protein 365 (ZNF365), transcript variant A, mRNA. (from RefSeq NM_014951) RefSeq Summary (NM_014951): This gene encodes a zinc finger protein that may play a role in the repair of DNA damage and maintenance of genome stability. The N-terminal C2H2 zinc finger motif is required to form a protein complex with PARP1 and MRE11, which are known to be involved in the restart of stalled DNA replication forks. A mutation in this gene may be associated with breast cancer susceptibility. [provided by RefSeq, Mar 2020]. Gencode Transcript: ENST00000395254.8 Gencode Gene: ENSG00000138311.18 Transcript (Including UTRs) Position: hg38 chr10:62,374,369-62,402,450 Size: 28,082 Total Exon Count: 5 Strand: + Coding Region Position: hg38 chr10:62,376,194-62,399,789 Size: 23,596 Coding Exon Count: 4
ID:ZN365_HUMAN DESCRIPTION: RecName: Full=Protein ZNF365; AltName: Full=Protein su48; SUBUNIT: Homodimer. Interacts with NDE1 and NDEL1. Does not interact with TUBG1. INTERACTION: Q9NXR1:NDE1; NbExp=4; IntAct=EBI-941182, EBI-941227; SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome. Note=localizes to the centrosome at all stages of the cell cycle. TISSUE SPECIFICITY: Isoform 1 is expressed in brain. Isoform 2 is expressed in placenta and at low level in lung and liver. Isoform 3 is expressed in kidney and pancreas. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR (By similarity). SEQUENCE CAUTION: Sequence=AAH17841.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=BAA74867.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q70YC5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
