Human Gene TACR2 (ENST00000373306.5) from GENCODE V44
  Description: Homo sapiens tachykinin receptor 2 (TACR2), mRNA. (from RefSeq NM_001057)
RefSeq Summary (NM_001057): This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neuropeptide substance K, also referred to as neurokinin A. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because transcript sequence consistent with the reference genome assembly was not available for all regions of the RefSeq transcript. The extent of this transcript is supported by transcript alignments.
Gencode Transcript: ENST00000373306.5
Gencode Gene: ENSG00000075073.16
Transcript (Including UTRs)
   Position: hg38 chr10:69,403,903-69,416,918 Size: 13,016 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg38 chr10:69,404,826-69,416,323 Size: 11,498 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:69,403,903-69,416,918)mRNA (may differ from genome)Protein (398 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: NK2R_HUMAN
DESCRIPTION: RecName: Full=Substance-K receptor; Short=SKR; AltName: Full=NK-2 receptor; Short=NK-2R; AltName: Full=Neurokinin A receptor; AltName: Full=Tachykinin receptor 2;
FUNCTION: This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: TACR2
Diseases sorted by gene-association score: retinitis pigmentosa 68 (3)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 102.59 RPKM in Colon - Sigmoid
Total median expression: 261.32 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -216.60595-0.364 Picture PostScript Text
3' UTR -257.00923-0.278 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR001681 - Neurokn_rcpt
IPR000913 - NK2_rcpt

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

ModBase Predicted Comparative 3D Structure on P21452
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004995 tachykinin receptor activity
GO:0005515 protein binding
GO:0016497 substance K receptor activity

Biological Process:
GO:0006936 muscle contraction
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007217 tachykinin receptor signaling pathway
GO:0007268 chemical synaptic transmission
GO:0007588 excretion
GO:0014057 positive regulation of acetylcholine secretion, neurotransmission
GO:0014827 intestine smooth muscle contraction
GO:0033685 negative regulation of luteinizing hormone secretion
GO:0035106 operant conditioning
GO:0043117 positive regulation of vascular permeability
GO:0043270 positive regulation of ion transport
GO:0045987 positive regulation of smooth muscle contraction
GO:0051602 response to electrical stimulus
GO:0070459 prolactin secretion
GO:0070472 regulation of uterine smooth muscle contraction
GO:0070474 positive regulation of uterine smooth muscle contraction
GO:1902093 positive regulation of flagellated sperm motility

Cellular Component:
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0036126 sperm flagellum
GO:0097225 sperm midpiece


-  Descriptions from all associated GenBank mRNAs
  AK096906 - Homo sapiens cDNA FLJ39587 fis, clone SKMUS2008407, highly similar to SUBSTANCE-K RECEPTOR.
BC033742 - Homo sapiens tachykinin receptor 2, mRNA (cDNA clone IMAGE:5190597), containing frame-shift errors.
AK291996 - Homo sapiens cDNA FLJ78621 complete cds, highly similar to Homo sapiens tachykinin receptor 2 (TACR2), mRNA.
AK300649 - Homo sapiens cDNA FLJ59268 complete cds, highly similar to Substance-K receptor.
AY322545 - Homo sapiens tachykinin receptor 2 mRNA, complete cds.
BC096842 - Homo sapiens tachykinin receptor 2, mRNA (cDNA clone MGC:111762 IMAGE:6971906), complete cds.
FJ200479 - Homo sapiens tachykinin receptor 2 variant mRNA, complete cds.
M57414 - Human neurokinin A receptor (NK-2R) mRNA, complete cds.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04020 - Calcium signaling pathway
hsa04080 - Neuroactive ligand-receptor interaction

Reactome (by CSHL, EBI, and GO)

Protein P21452 (Reactome details) participates in the following event(s):

R-HSA-383363 Tachykinin receptor 2 (NK2) binds to nuerokinin A
R-HSA-749452 The Ligand:GPCR:Gq complex dissociates
R-HSA-749448 Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
R-HSA-379048 Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
R-HSA-380095 Tachykinin receptors bind tachykinins
R-HSA-416476 G alpha (q) signalling events
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-388396 GPCR downstream signalling
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-372790 Signaling by GPCR
R-HSA-500792 GPCR ligand binding
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: A8K7I1, ENST00000373306.1, ENST00000373306.2, ENST00000373306.3, ENST00000373306.4, NK2R, NK2R_HUMAN, NKNAR, NM_001057, P21452, Q4QRI5, Q8NGQ8, Q9UDE6, Q9UDE7, TAC2R, uc001jpn.1, uc001jpn.2, uc001jpn.3, uc001jpn.4
UCSC ID: ENST00000373306.5
RefSeq Accession: NM_001057
Protein: P21452 (aka NK2R_HUMAN)
CCDS: CCDS7293.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.