Human Gene UNC5B (ENST00000335350.10) from GENCODE V44
Description: Homo sapiens unc-5 netrin receptor B (UNC5B), transcript variant 1, mRNA. (from RefSeq NM_170744) RefSeq Summary (NM_170744): This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]. Gencode Transcript: ENST00000335350.10 Gencode Gene: ENSG00000107731.12 Transcript (Including UTRs) Position: hg38 chr10:71,212,570-71,302,864 Size: 90,295 Total Exon Count: 17 Strand: + Coding Region Position: hg38 chr10:71,212,986-71,299,277 Size: 86,292 Coding Exon Count: 17
ID:UNC5B_HUMAN DESCRIPTION: RecName: Full=Netrin receptor UNC5B; AltName: Full=Protein unc-5 homolog 2; AltName: Full=Protein unc-5 homolog B; AltName: Full=p53-regulated receptor for death and life protein 1; Flags: Precursor; FUNCTION: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity. SUBUNIT: Interacts with the cytoplasmic part of DCC (By similarity). Interacts with GNAI2 via its cytoplasmic part. Interacts (via death domain) with DAPK1 (via death domain). INTERACTION: Q8CGU4:Agap2 (xeno); NbExp=9; IntAct=EBI-4409075, EBI-4409108; SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. Note=Associated with lipid raft. TISSUE SPECIFICITY: Highly expressed in brain. Also expressed at lower level in developing lung, cartilage, kidney and hematopoietic and immune tissues. INDUCTION: By p53/TP53. PTM: Phosphorylated on cytoplasmic tyrosine residues (By similarity). PTM: Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis. PTM: Palmitoylation target the protein to the lipid rafts, and is required for pro-apoptotic activity. MISCELLANEOUS: Down-regulated in multiple cancers including colorectal, breast, ovary, uterus, stomach, lung, or kidney cancers. SIMILARITY: Belongs to the unc-5 family. SIMILARITY: Contains 1 death domain. SIMILARITY: Contains 1 Ig-like (immunoglobulin-like) domain. SIMILARITY: Contains 1 Ig-like C2-type (immunoglobulin-like) domain. SIMILARITY: Contains 2 TSP type-1 domains. SIMILARITY: Contains 1 ZU5 domain. SEQUENCE CAUTION: Sequence=BAB14276.1; Type=Erroneous initiation; Sequence=BAC04382.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8IZJ1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
