Human Gene DUSP29 (ENST00000338487.6) from GENCODE V44
  Description: Homo sapiens dual specificity phosphatase 29 (DUSP29), transcript variant 2, mRNA. (from RefSeq NM_001384909)
Gencode Transcript: ENST00000338487.6
Gencode Gene: ENSG00000188716.6
Transcript (Including UTRs)
   Position: hg38 chr10:75,037,472-75,073,642 Size: 36,171 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg38 chr10:75,037,836-75,058,514 Size: 20,679 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersRNA-Seq ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:75,037,472-75,073,642)mRNA (may differ from genome)Protein (220 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGencodeGeneCardsHPRD
MalacardsMGIneXtProtOMIMPubMedUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: DUPD1_HUMAN
DESCRIPTION: RecName: Full=Dual specificity phosphatase DUPD1; EC=3.1.3.16; EC=3.1.3.48; AltName: Full=Dual specificity phosphatase 27;
CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein + phosphate.
SUBUNIT: Homodimer.
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Skeletal muscle, liver and adipose tissue.
SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
SIMILARITY: Contains 1 tyrosine-protein phosphatase domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 18.95 RPKM in Muscle - Skeletal
Total median expression: 19.48 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -39.40108-0.365 Picture PostScript Text
3' UTR -127.50364-0.350 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR020417 - Atypical_DUSP
IPR020405 - Atypical_DUSP_famA
IPR000340 - Dual-sp_phosphatase_cat-dom
IPR020422 - Dual-sp_phosphatase_subgr_cat
IPR024950 - DUSP
IPR000387 - Tyr/Dual-specificity_Pase
IPR016130 - Tyr_Pase_AS

Pfam Domains:
PF00782 - Dual specificity phosphatase, catalytic domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2Y96 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q68J44
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity
GO:0042803 protein homodimerization activity

Biological Process:
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation

Cellular Component:
GO:0005737 cytoplasm
GO:0032991 macromolecular complex


-  Descriptions from all associated GenBank mRNAs
  BC137321 - Homo sapiens dual specificity phosphatase and pro isomerase domain containing 1, mRNA (cDNA clone MGC:168941 IMAGE:9021318), complete cds.
BC137322 - Homo sapiens dual specificity phosphatase and pro isomerase domain containing 1, mRNA (cDNA clone MGC:168942 IMAGE:9021319), complete cds.
AY686755 - Homo sapiens FMDSP mRNA, complete cds.
KJ896046 - Synthetic construct Homo sapiens clone ccsbBroadEn_05440 DUPD1 gene, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: B2RP93, DUPD1, DUPD1_HUMAN, DUSP27, ENST00000338487.1, ENST00000338487.2, ENST00000338487.3, ENST00000338487.4, ENST00000338487.5, NM_001384909, Q68J44, uc001jwq.1, uc001jwq.2
UCSC ID: ENST00000338487.6
RefSeq Accession: NM_001003892
Protein: Q68J44 (aka DUPD1_HUMAN)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.