Human Gene PLEKHS1 (ENST00000619563.5) from GENCODE V44
Description: Homo sapiens pleckstrin homology domain containing S1 (PLEKHS1), transcript variant 3, mRNA. (from RefSeq NM_001193435)
Gencode Transcript: ENST00000619563.5
Gencode Gene: ENSG00000148735.16
Transcript (Including UTRs)
Position: hg38 chr10:113,751,682-113,781,237 Size: 29,556 Total Exon Count: 11 Strand: +
Coding Region
Position: hg38 chr10:113,767,385-113,780,781 Size: 13,397 Coding Exon Count: 9
Data last updated at UCSC: 2023-08-18 00:09:47
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: PKHS1_HUMAN
DESCRIPTION: RecName: Full=Pleckstrin homology domain-containing family S member 1; Short=PH domain-containing family S member 1; AltName: Full=Epididymis luminal protein 185; Short=hEL185;
SIMILARITY: Contains 1 PH domain.SEQUENCE CAUTION: Sequence=AAH36365.2; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAB15687.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAI12642.1; Type=Erroneous gene model prediction; Sequence=CAI12643.1; Type=Erroneous gene model prediction; Sequence=CAI12644.1; Type=Erroneous gene model prediction;
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
Press "+" in the title bar above to open this section.
mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR011993 - PH_like_dom
IPR001849 - Pleckstrin_homology
ModBase Predicted Comparative 3D Structure on Q5SXH7
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AK128811 - Homo sapiens cDNA FLJ46008 fis, clone SMINT2017964.AK292867 - Homo sapiens cDNA FLJ77649 complete cds.AK126354 - Homo sapiens cDNA FLJ44383 fis, clone TRACH3036207.AB528876 - Synthetic construct DNA, clone: pF1KE0610, Homo sapiens C10orf81 gene for chromosome 10 open reading frame 81, without stop codon, in Flexi system.BC037870 - Homo sapiens chromosome 10 open reading frame 81, mRNA (cDNA clone MGC:43838 IMAGE:5273287), complete cds.FJ236306 - Homo sapiens testis secretory sperm binding protein Li 244mP (HTL-S-244mP) mRNA, complete cds.GQ900988 - Homo sapiens clone HEL-T-100 epididymis secretory sperm binding protein mRNA, complete cds.BC036365 - Homo sapiens chromosome 10 open reading frame 81, mRNA (cDNA clone IMAGE:4825959), partial cds.KJ903254 - Synthetic construct Homo sapiens clone ccsbBroadEn_12648 C10orf81 gene, encodes complete protein.CU690334 - Synthetic construct Homo sapiens gateway clone IMAGE:100018719 5' read C10orf81 mRNA.JD309970 - Sequence 290994 from Patent EP1572962.AK027190 - Homo sapiens cDNA: FLJ23537 fis, clone LNG07690.JD268097 - Sequence 249121 from Patent EP1572962.AK296132 - Homo sapiens cDNA FLJ51608 complete cds.JD190207 - Sequence 171231 from Patent EP1572962.JD044419 - Sequence 25443 from Patent EP1572962.JD447482 - Sequence 428506 from Patent EP1572962.JD204188 - Sequence 185212 from Patent EP1572962.JD161198 - Sequence 142222 from Patent EP1572962.JD117683 - Sequence 98707 from Patent EP1572962.JD392185 - Sequence 373209 from Patent EP1572962.JD356113 - Sequence 337137 from Patent EP1572962.JD278932 - Sequence 259956 from Patent EP1572962.JD438491 - Sequence 419515 from Patent EP1572962.JD438492 - Sequence 419516 from Patent EP1572962.JD530443 - Sequence 511467 from Patent EP1572962.JD515290 - Sequence 496314 from Patent EP1572962.JD322070 - Sequence 303094 from Patent EP1572962.JD322069 - Sequence 303093 from Patent EP1572962.JD322075 - Sequence 303099 from Patent EP1572962.JD322079 - Sequence 303103 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: A8KA02, B3KX00, B6EDE1, C10orf81, ENST00000619563.1, ENST00000619563.2, ENST00000619563.3, ENST00000619563.4, NM_001193435, PKHS1_HUMAN, Q5SXH7, Q5SXH8, Q5SXI0, Q6ZQR5, Q8NE42, Q9H5D9, uc001las.1, uc001las.2, uc001las.3, uc001las.4UCSC ID: ENST00000619563.5RefSeq Accession: NM_001193435
Protein: Q5SXH7
(aka PKHS1_HUMAN)
CCDS: CCDS53581.1
Methods, Credits, and Use Restrictions
Click here
for details on how this gene model was made and data restrictions if any.