Human Gene OR5P2 (ENST00000329434.3) from GENCODE V44
  Description: Homo sapiens olfactory receptor family 5 subfamily P member 2 (OR5P2), mRNA. (from RefSeq NM_153444)
RefSeq Summary (NM_153444): Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000329434.3
Gencode Gene: ENSG00000183303.3
Transcript (Including UTRs)
   Position: hg38 chr11:7,795,974-7,796,942 Size: 969 Total Exon Count: 1 Strand: -
Coding Region
   Position: hg38 chr11:7,795,974-7,796,942 Size: 969 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:7,795,974-7,796,942)mRNA (may differ from genome)Protein (322 aa)
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HGNCHPRDMGIneXtProtPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: OR5P2_HUMAN
DESCRIPTION: RecName: Full=Olfactory receptor 5P2; AltName: Full=Olfactory receptor-like protein JCG3;
FUNCTION: Odorant receptor (Potential). May be involved in taste perception.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed in the tongue.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE); URL="http://bip.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR5P2";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.15 RPKM in Skin - Not Sun Exposed (Suprapubic)
Total median expression: 0.39 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR000725 - Olfact_rcpt

ModBase Predicted Comparative 3D Structure on Q8WZ92
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004984 olfactory receptor activity
GO:0005549 odorant binding

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007608 sensory perception of smell
GO:0050896 response to stimulus
GO:0050911 detection of chemical stimulus involved in sensory perception of smell

Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC113557 - Homo sapiens olfactory receptor, family 5, subfamily P, member 2, mRNA (cDNA clone MGC:142117 IMAGE:8322609), complete cds.
BC101710 - Homo sapiens olfactory receptor, family 5, subfamily P, member 2, mRNA (cDNA clone MGC:126759 IMAGE:8069216), complete cds.
AF173006 - Homo sapiens olfactory receptor-like protein JCG3 (JCG3) mRNA, complete cds.
HQ258379 - Synthetic construct Homo sapiens clone IMAGE:100072808 olfactory receptor, family 5, subfamily P, member 2 (OR5P2) gene, encodes complete protein.
KJ895349 - Synthetic construct Homo sapiens clone ccsbBroadEn_04743 OR5P2 gene, encodes complete protein.
LF207843 - JP 2014500723-A/15346: Polycomb-Associated Non-Coding RNAs.
MA443420 - JP 2018138019-A/15346: Polycomb-Associated Non-Coding RNAs.
AF220494 - Homo sapiens olfactory receptor-like protein JCG4 (JCG4) mRNA, partial cds.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8WZ92 (Reactome details) participates in the following event(s):

R-HSA-381750 Olfactory Receptor - G Protein olfactory trimer complex formation
R-HSA-381753 Olfactory Signaling Pathway
R-HSA-418555 G alpha (s) signalling events
R-HSA-388396 GPCR downstream signalling
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000329434.1, ENST00000329434.2, NM_153444, OR5P2_HUMAN, Q3MIS8, Q8WZ92, uc001mfp.1, uc001mfp.2, uc001mfp.3
UCSC ID: ENST00000329434.3
RefSeq Accession: NM_153444
Protein: Q8WZ92 (aka OR5P2_HUMAN or O5P2_HUMAN)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.