Human Gene MUC15 (ENST00000455601.6) from GENCODE V44
  Description: Homo sapiens mucin 15, cell surface associated (MUC15), transcript variant 2, mRNA. (from RefSeq NM_145650)
Gencode Transcript: ENST00000455601.6
Gencode Gene: ENSG00000169550.14
Transcript (Including UTRs)
   Position: hg38 chr11:26,559,033-26,572,121 Size: 13,089 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg38 chr11:26,561,065-26,565,858 Size: 4,794 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:26,559,033-26,572,121)mRNA (may differ from genome)Protein (334 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedReactomeUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: MUC15_HUMAN
DESCRIPTION: RecName: Full=Mucin-15; Short=MUC-15; Flags: Precursor;
FUNCTION: May play a role in the cell adhesion to the extracellular matrix.
SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein (Potential).
SUBCELLULAR LOCATION: Isoform 2: Secreted (Potential).
TISSUE SPECIFICITY: Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocyte, bone marrow, lymph node and lung.
PTM: Highly glycosylated (N- and O-linked carbohydrates) (By similarity).
SEQUENCE CAUTION: Sequence=AAH20912.2; Type=Erroneous termination; Positions=335; Note=Translated as stop;
WEB RESOURCE: Name=Mucin database; URL="http://www.medkem.gu.se/mucinbiology/databases/";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: MUC15
Diseases sorted by gene-association score: colorectal cancer 1 (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 18.99 RPKM in Thyroid
Total median expression: 69.53 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -11.80119-0.099 Picture PostScript Text
3' UTR -448.402032-0.221 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on Q8N387
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein SequenceProtein Sequence   
AlignmentAlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0016266 O-glycan processing

Cellular Component:
GO:0005576 extracellular region
GO:0005796 Golgi lumen
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK128337 - Homo sapiens cDNA FLJ46479 fis, clone THYMU3025642, highly similar to Mucin-15 precursor.
AK026790 - Homo sapiens cDNA: FLJ23137 fis, clone LNG08842.
AY358668 - Homo sapiens clone DNA58732 MUC15 (UNQ750) mRNA, complete cds.
BC058007 - Homo sapiens mucin 15, cell surface associated, mRNA (cDNA clone MGC:62123 IMAGE:4719841), complete cds.
BC020912 - Homo sapiens mucin 15, cell surface associated, mRNA (cDNA clone MGC:24172 IMAGE:4733074), complete cds.
AJ507429 - Homo sapiens mRNA for MUC15/S protein, short variant (MUC15 gene).
AJ417818 - Homo sapiens mRNA for MUC15 protein.
JD240051 - Sequence 221075 from Patent EP1572962.
HQ447702 - Synthetic construct Homo sapiens clone IMAGE:100071030; CCSB013284_01 mucin 15, cell surface associated (MUC15) gene, encodes complete protein.
KJ900211 - Synthetic construct Homo sapiens clone ccsbBroadEn_09605 MUC15 gene, encodes complete protein.
CU691284 - Synthetic construct Homo sapiens gateway clone IMAGE:100022178 5' read MUC15 mRNA.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8N387 (Reactome details) participates in the following event(s):

R-HSA-913675 GALNTs transfer GalNAc from UDP-GalNAc to mucins to form Tn antigens
R-HSA-914012 GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins
R-HSA-977228 Sialyltransferase I can add sialic acid to the T antigen at the alpha 6 position
R-HSA-981497 ST3GAL1-4 can add a sialic acid to the T antigen at the alpha 3 position
R-HSA-981814 GalNAc alpha-2,6-sialyltransferase II can add a sialic acid to the T antigen at the alpha 6 position
R-HSA-1964505 C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens)
R-HSA-1964501 Addition of galactose to Core 6 glycoprotein
R-HSA-5694487 A4GNT transfers GlcNAc to core 2 mucins
R-HSA-6786012 CHST4 transfers SO4(2-) from PAPS to Core 2 mucins
R-HSA-914018 Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein
R-HSA-914010 Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein
R-HSA-977071 Sialyltransferase I can add sialic acid to the Tn antigen at the alpha 6 position
R-HSA-981809 ST6GALNAC3/4 can add a sialic acid to the sialyl T antigen to form the disialyl T antigen
R-HSA-8858500 CLEC10A binds Tn-MUC1
R-HSA-913709 O-linked glycosylation of mucins
R-HSA-5083636 Defective GALNT12 causes colorectal cancer 1 (CRCS1)
R-HSA-5083625 Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)
R-HSA-977068 Termination of O-glycan biosynthesis
R-HSA-5083632 Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
R-HSA-5621480 Dectin-2 family
R-HSA-5173105 O-linked glycosylation
R-HSA-3906995 Diseases associated with O-glycosylation of proteins
R-HSA-5621481 C-type lectin receptors (CLRs)
R-HSA-597592 Post-translational protein modification
R-HSA-3781865 Diseases of glycosylation
R-HSA-168249 Innate Immune System
R-HSA-392499 Metabolism of proteins
R-HSA-1643685 Disease
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: B3KY00, ENST00000455601.1, ENST00000455601.2, ENST00000455601.3, ENST00000455601.4, ENST00000455601.5, MUC15_HUMAN, NM_145650, Q6UWS3, Q8IXI8, Q8N387, Q8WW41, uc001mqx.1, uc001mqx.2, uc001mqx.3, uc001mqx.4, UNQ750/PRO1481
UCSC ID: ENST00000455601.6
RefSeq Accession: NM_145650
Protein: Q8N387 (aka MUC15_HUMAN or MU15_HUMAN)
CCDS: CCDS7859.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.