ID:MUC15_HUMAN DESCRIPTION: RecName: Full=Mucin-15; Short=MUC-15; Flags: Precursor; FUNCTION: May play a role in the cell adhesion to the extracellular matrix. SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein (Potential). SUBCELLULAR LOCATION: Isoform 2: Secreted (Potential). TISSUE SPECIFICITY: Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocyte, bone marrow, lymph node and lung. PTM: Highly glycosylated (N- and O-linked carbohydrates) (By similarity). SEQUENCE CAUTION: Sequence=AAH20912.2; Type=Erroneous termination; Positions=335; Note=Translated as stop; WEB RESOURCE: Name=Mucin database; URL="http://www.medkem.gu.se/mucinbiology/databases/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
ModBase Predicted Comparative 3D Structure on Q8N387
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK128337 - Homo sapiens cDNA FLJ46479 fis, clone THYMU3025642, highly similar to Mucin-15 precursor. AK026790 - Homo sapiens cDNA: FLJ23137 fis, clone LNG08842. AY358668 - Homo sapiens clone DNA58732 MUC15 (UNQ750) mRNA, complete cds. BC058007 - Homo sapiens mucin 15, cell surface associated, mRNA (cDNA clone MGC:62123 IMAGE:4719841), complete cds. BC020912 - Homo sapiens mucin 15, cell surface associated, mRNA (cDNA clone MGC:24172 IMAGE:4733074), complete cds. AJ507429 - Homo sapiens mRNA for MUC15/S protein, short variant (MUC15 gene). AJ417818 - Homo sapiens mRNA for MUC15 protein. JD240051 - Sequence 221075 from Patent EP1572962. HQ447702 - Synthetic construct Homo sapiens clone IMAGE:100071030; CCSB013284_01 mucin 15, cell surface associated (MUC15) gene, encodes complete protein. KJ900211 - Synthetic construct Homo sapiens clone ccsbBroadEn_09605 MUC15 gene, encodes complete protein. CU691284 - Synthetic construct Homo sapiens gateway clone IMAGE:100022178 5' read MUC15 mRNA.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q8N387 (Reactome details) participates in the following event(s):
R-HSA-913675 GALNTs transfer GalNAc from UDP-GalNAc to mucins to form Tn antigens R-HSA-914012 GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins R-HSA-977228 Sialyltransferase I can add sialic acid to the T antigen at the alpha 6 position R-HSA-981497 ST3GAL1-4 can add a sialic acid to the T antigen at the alpha 3 position R-HSA-981814 GalNAc alpha-2,6-sialyltransferase II can add a sialic acid to the T antigen at the alpha 6 position R-HSA-1964505 C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) R-HSA-1964501 Addition of galactose to Core 6 glycoprotein R-HSA-5694487 A4GNT transfers GlcNAc to core 2 mucins R-HSA-6786012 CHST4 transfers SO4(2-) from PAPS to Core 2 mucins R-HSA-914018 Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein R-HSA-914010 Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein R-HSA-977071 Sialyltransferase I can add sialic acid to the Tn antigen at the alpha 6 position R-HSA-981809 ST6GALNAC3/4 can add a sialic acid to the sialyl T antigen to form the disialyl T antigen R-HSA-8858500 CLEC10A binds Tn-MUC1 R-HSA-913709 O-linked glycosylation of mucins R-HSA-5083636 Defective GALNT12 causes colorectal cancer 1 (CRCS1) R-HSA-5083625 Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) R-HSA-977068 Termination of O-glycan biosynthesis R-HSA-5083632 Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) R-HSA-5621480 Dectin-2 family R-HSA-5173105 O-linked glycosylation R-HSA-3906995 Diseases associated with O-glycosylation of proteins R-HSA-5621481 C-type lectin receptors (CLRs) R-HSA-597592 Post-translational protein modification R-HSA-3781865 Diseases of glycosylation R-HSA-168249 Innate Immune System R-HSA-392499 Metabolism of proteins R-HSA-1643685 Disease R-HSA-168256 Immune System