Human Gene IFTAP (ENST00000347206.8) from GENCODE V44
  Description: Homo sapiens intraflagellar transport associated protein (IFTAP), transcript variant 7, mRNA. (from RefSeq NM_001276727)
RefSeq Summary (NM_001276727): This gene encodes a protein that was identified as a cellular interacting partner of non-structural protein 10 of the severe acute respiratory syndrome coronavirus (SARS-CoV). The encoded protein may function as a negative regulator of transcription. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013].
Gencode Transcript: ENST00000347206.8
Gencode Gene: ENSG00000166352.18
Transcript (Including UTRs)
   Position: hg38 chr11:36,594,513-36,659,272 Size: 64,760 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg38 chr11:36,610,104-36,659,186 Size: 49,083 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:36,594,513-36,659,272)mRNA (may differ from genome)Protein (147 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGencodeGeneCardsHPRD
MalacardsMGIneXtProtPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CK074_HUMAN
DESCRIPTION: RecName: Full=Uncharacterized protein C11orf74; AltName: Full=Protein HEPIS;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 38.38 RPKM in Testis
Total median expression: 406.19 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -26.50103-0.257 Picture PostScript Text
3' UTR -17.0086-0.198 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on Q86VG3
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0005929 cilium


-  Descriptions from all associated GenBank mRNAs
  AK290833 - Homo sapiens cDNA FLJ76614 complete cds, highly similar to Homo sapiens HEPIS, mRNA.
DQ121386 - Homo sapiens HEPIS mRNA, complete cds.
AK299642 - Homo sapiens cDNA FLJ51662 complete cds.
AK095997 - Homo sapiens cDNA FLJ38678 fis, clone KIDNE2000227.
BC009561 - Homo sapiens chromosome 11 open reading frame 74, mRNA (cDNA clone MGC:10116 IMAGE:3900485), complete cds.
JD048312 - Sequence 29336 from Patent EP1572962.
JD263023 - Sequence 244047 from Patent EP1572962.
BC051031 - Homo sapiens chromosome 11 open reading frame 74, mRNA (cDNA clone MGC:54287 IMAGE:5122890), complete cds.
JD077100 - Sequence 58124 from Patent EP1572962.
AK302634 - Homo sapiens cDNA FLJ51661 complete cds.
CU690796 - Synthetic construct Homo sapiens gateway clone IMAGE:100021316 5' read C11orf74 mRNA.
HQ448648 - Synthetic construct Homo sapiens clone IMAGE:100072087; CCSB011463_02 chromosome 11 open reading frame 74 (C11orf74) gene, encodes complete protein.
JF432765 - Synthetic construct Homo sapiens clone IMAGE:100074009 chromosome 11 open reading frame 74 (C11orf74) gene, encodes complete protein.
KJ895346 - Synthetic construct Homo sapiens clone ccsbBroadEn_04740 C11orf74 gene, encodes complete protein.
KJ903683 - Synthetic construct Homo sapiens clone ccsbBroadEn_13077 C11orf74 gene, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: C11orf74, CK074_HUMAN, D3DR18, ENST00000347206.1, ENST00000347206.2, ENST00000347206.3, ENST00000347206.4, ENST00000347206.5, ENST00000347206.6, ENST00000347206.7, NM_001276727, Q86VG3, Q96DD6, uc001mwz.1, uc001mwz.2, uc001mwz.3
UCSC ID: ENST00000347206.8
RefSeq Accession: NM_001276727
Protein: Q86VG3 (aka CK074_HUMAN)
CCDS: CCDS60762.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.