Human Gene MS4A3 (ENST00000358152.6) from GENCODE V44
Description: Homo sapiens membrane spanning 4-domains A3 (MS4A3), transcript variant 2, mRNA. (from RefSeq NM_001031809) RefSeq Summary (NM_001031809): This gene encodes a member of the membrane-spanning 4A gene family. Members of this protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member likely plays a role in signal transduction and may function as a subunit associated with receptor complexes. The gene encoding this protein is localized to 11q12, among a cluster of related family members. Alternative splicing may result in multiple transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000358152.6 Gencode Gene: ENSG00000149516.14 Transcript (Including UTRs) Position: hg38 chr11:60,056,628-60,071,114 Size: 14,487 Total Exon Count: 6 Strand: + Coding Region Position: hg38 chr11:60,061,161-60,070,233 Size: 9,073 Coding Exon Count: 5
ID:MS4A3_HUMAN DESCRIPTION: RecName: Full=Membrane-spanning 4-domains subfamily A member 3; AltName: Full=CD20 antigen-like protein; AltName: Full=Hematopoietic-specific transmembrane protein 4; Short=HTm4; FUNCTION: Hematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of cyclin- dependent kinase 2 (CDK2) through its direct binding to cyclin- dependent kinase inhibitor 3 (CDKN3/KAP). SUBUNIT: Interacts with CDKN3. Interacts with CDKN3-CDK2 complexes through its binding to CDKN3; this interaction facilitates dissociation of cyclin A from CDKN3-CDK2 complexes. SUBCELLULAR LOCATION: Endomembrane system; Multi-pass membrane protein (By similarity). Cytoplasm, perinuclear region (By similarity). Note=Located in the perinuclear area. TISSUE SPECIFICITY: Expressed specifically in hematopoietic cells and tissues. DOMAIN: The C-terminal region is required for binding to CDKN3- CDK2 complexes and the modulation of CDKN3 activity. SIMILARITY: Belongs to the MS4A family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96HJ5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
