Human Gene MS4A10 (ENST00000308287.2) from GENCODE V44
  Description: Homo sapiens membrane spanning 4-domains A10 (MS4A10), mRNA. (from RefSeq NM_206893)
RefSeq Summary (NM_206893): Most MS4A genes, including MS4A10, encode proteins with at least 4 potential transmembrane domains and N- and C-terminal cytoplasmic domains encoded by distinct exons.[supplied by OMIM, Apr 2004]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because transcript sequence consistent with the reference genome assembly was not available for all regions of the RefSeq transcript. The extent of this transcript is supported by transcript alignments.
Gencode Transcript: ENST00000308287.2
Gencode Gene: ENSG00000172689.2
Transcript (Including UTRs)
   Position: hg38 chr11:60,785,333-60,801,305 Size: 15,973 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg38 chr11:60,790,336-60,799,909 Size: 9,574 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:60,785,333-60,801,305)mRNA (may differ from genome)Protein (267 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMGIneXtProtOMIM
PubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: M4A10_HUMAN
DESCRIPTION: RecName: Full=Membrane-spanning 4-domains subfamily A member 10; AltName: Full=CD20 antigen-like 7;
FUNCTION: May be involved in signal transduction as a component of a multimeric receptor complex.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (By similarity).
SIMILARITY: Belongs to the MS4A family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 23.41 RPKM in Small Intestine - Terminal Ileum
Total median expression: 23.58 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -40.40111-0.364 Picture PostScript Text
3' UTR -448.801396-0.321 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007237 - CD20-like

Pfam Domains:
PF04103 - CD20-like family

ModBase Predicted Comparative 3D Structure on Q96PG2
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK122633 - Homo sapiens cDNA FLJ16054 fis, clone SMINT2009902.
BC137259 - Homo sapiens membrane-spanning 4-domains, subfamily A, member 10, mRNA (cDNA clone MGC:168879 IMAGE:9021256), complete cds.
BC137263 - Homo sapiens membrane-spanning 4-domains, subfamily A, member 10, mRNA (cDNA clone MGC:168883 IMAGE:9021260), complete cds.
KJ896085 - Synthetic construct Homo sapiens clone ccsbBroadEn_05479 MS4A10 gene, encodes complete protein.
JD213287 - Sequence 194311 from Patent EP1572962.
JD463218 - Sequence 444242 from Patent EP1572962.
JD489207 - Sequence 470231 from Patent EP1572962.
JD198359 - Sequence 179383 from Patent EP1572962.
JD153063 - Sequence 134087 from Patent EP1572962.
JD160904 - Sequence 141928 from Patent EP1572962.
JD513631 - Sequence 494655 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B2RP45, CD20L7, ENST00000308287.1, M4A10_HUMAN, MS4A9, NM_206893, Q96PG2, Q96PG3, uc001npz.1, uc001npz.2
UCSC ID: ENST00000308287.2
RefSeq Accession: NM_206893
Protein: Q96PG2 (aka M4A10_HUMAN or M4AA_HUMAN)
CCDS: CCDS7992.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.