Human Gene BRMS1 (ENST00000425825.6) from GENCODE V44
Description: Homo sapiens BRMS1 transcriptional repressor and anoikis regulator (BRMS1), transcript variant 2, mRNA. (from RefSeq NM_001024957) RefSeq Summary (NM_001024957): This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000425825.6 Gencode Gene: ENSG00000174744.14 Transcript (Including UTRs) Position: hg38 chr11:66,337,333-66,345,119 Size: 7,787 Total Exon Count: 10 Strand: - Coding Region Position: hg38 chr11:66,337,668-66,342,234 Size: 4,567 Coding Exon Count: 9
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on G5E9I4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
