Human Gene GSTP1 (ENST00000398606.10) from GENCODE V44
Description: Homo sapiens glutathione S-transferase pi 1 (GSTP1), mRNA. (from RefSeq NM_000852) RefSeq Summary (NM_000852): Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000398606.10 Gencode Gene: ENSG00000084207.18 Transcript (Including UTRs) Position: hg38 chr11:67,583,812-67,586,653 Size: 2,842 Total Exon Count: 7 Strand: + Coding Region Position: hg38 chr11:67,583,844-67,586,577 Size: 2,734 Coding Exon Count: 7
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
D28456 - Homo sapiens mRNA for glutathione S-transferase Pi, 5'UTR region. AY887902 - Homo sapiens mutant GSTP1 (GSTP1) mRNA, complete cds. BC010915 - Homo sapiens glutathione S-transferase pi 1, mRNA (cDNA clone MGC:13474 IMAGE:3960700), complete cds. EU794620 - Homo sapiens epididymis secretory protein Li 22 (HEL-S-22) mRNA, complete cds. BC044846 - Homo sapiens glutathione S-transferase pi 1, mRNA (cDNA clone IMAGE:5162861), with apparent retained intron. X15480 - Human mRNA for anionic glutathione-S-transferase (GST-pi-1). U62589 - Human glutathione S-transferase P1c (GSTp1c) mRNA, complete cds. U30897 - Human glutathione S-transferase (P1b) mRNA, complete cds. AB527935 - Synthetic construct DNA, clone: pF1KB0973, Homo sapiens GSTP1 gene for glutathione S-transferase pi 1, without stop codon, in Flexi system. CR450361 - Homo sapiens full open reading frame cDNA clone RZPDo834C083D for gene GSTP1, glutathione S-transferase pi; complete cds; without stopcodon. BT019949 - Homo sapiens glutathione S-transferase pi mRNA, complete cds. BT019950 - Homo sapiens glutathione S-transferase pi mRNA, complete cds. DQ892738 - Synthetic construct clone IMAGE:100005368; FLH189249.01X; RZPDo839D0274D glutathione S-transferase pi (GSTP1) gene, encodes complete protein. DQ895985 - Synthetic construct Homo sapiens clone IMAGE:100010445; FLH189245.01L; RZPDo839D0264D glutathione S-transferase pi (GSTP1) gene, encodes complete protein. KJ896941 - Synthetic construct Homo sapiens clone ccsbBroadEn_06335 GSTP1 gene, encodes complete protein. AY579414 - Homo sapiens glutathione S-transferase pi-like mRNA, partial sequence. M69113 - Human fatty acid ethyl ester synthase-III mRNA sequence. X06547 - Human mRNA for class Pi glutathione S-transferase (GST-Pi; E.C.2.5.1.18). LF205523 - JP 2014500723-A/13026: Polycomb-Associated Non-Coding RNAs. MA441100 - JP 2018138019-A/13026: Polycomb-Associated Non-Coding RNAs. GQ141553 - Homo sapiens isolate PV-1A glutathione S-transferase pi (GSTP1) mRNA, partial cds. GQ141554 - Homo sapiens isolate PF-1A glutathione S-transferase pi (GSTP1) mRNA, partial cds. LF321463 - JP 2014500723-A/128966: Polycomb-Associated Non-Coding RNAs. MA557040 - JP 2018138019-A/128966: Polycomb-Associated Non-Coding RNAs. LF321462 - JP 2014500723-A/128965: Polycomb-Associated Non-Coding RNAs. MA557039 - JP 2018138019-A/128965: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa00480 - Glutathione metabolism hsa00980 - Metabolism of xenobiotics by cytochrome P450 hsa00982 - Drug metabolism - cytochrome P450 hsa05200 - Pathways in cancer hsa05215 - Prostate cancer