Human Gene LRRC51 (ENST00000289488.8) from GENCODE V44
Description: Homo sapiens leucine rich transmembrane and O-methyltransferase domain containing (LRTOMT), transcript variant 3, non-coding RNA. (from RefSeq NR_026886) RefSeq Summary (NM_145309): This gene has evolved in primates as a fusion of two ancestral neighboring genes, Lrrc51 and Tomt, which exist as two independent genes in rodents. The fusion gene contains some shared exons, but encodes structurally unrelated proteins, LRTOMT1 and LRTOMT2. Those variants that utilize the more centromere-proximal 3' terminal exon (short transcript form) encode LRTOMT1, while those variants that use a more centromere-distal 3' terminal exon (long transcript form) encode the LRTOMT2 protein. There is a small region within one of the exons of this gene that contains overlapping alternate reading frames for both LRTOMT1 and LRTOMT2. LRTOMT1 shares similarity with the protein encoded by mouse Lrrc51, while LRTOMT2 shares similarity with the protein encoded by mouse Tomt. Alternative splicing results in multiple transcript variants, encoding different isoforms of both LRTOMT1 and LRTOMT2. The LRTOMT1 protein is a leucine-rich repeat-containing protein, while the LRTOMT2 protein is a catechol-O-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to a hydroxyl group of catechols and is essential for auditory and vestibular function. Mutations in this gene have been associated with nonsyndromic deafness. [provided by RefSeq, Nov 2017]. Gencode Transcript: ENST00000289488.8 Gencode Gene: ENSG00000184154.16 Transcript (Including UTRs) Position: hg38 chr11:72,080,850-72,096,895 Size: 16,046 Total Exon Count: 6 Strand: + Coding Region Position: hg38 chr11:72,089,084-72,095,520 Size: 6,437 Coding Exon Count: 4
ID:LRC51_HUMAN DESCRIPTION: RecName: Full=Leucine-rich repeat-containing protein 51; AltName: Full=Protein LRTOMT1; SUBCELLULAR LOCATION: Cytoplasm (By similarity). MISCELLANEOUS: In primates, this protein is produced by a bicistronic gene which also produces the TOMT protein from an overlapping reading frame. In rodents, these proteins are produced by 2 separate adjacent genes which together are orthologous to the single primate gene. SIMILARITY: Contains 3 LRR (leucine-rich) repeats. SIMILARITY: Contains 1 LRRCT domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96E66
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
