Human Gene UCP3 (ENST00000426995.2) from GENCODE V44
Description: Homo sapiens uncoupling protein 3 (UCP3), transcript variant short, mRNA; nuclear gene for mitochondrial product. (from RefSeq NM_022803) RefSeq Summary (NM_022803): Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression; this gene is primarily expressed in skeletal muscle. This gene's protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants have been found for this gene.[provided by RefSeq, Nov 2008]. Gencode Transcript: ENST00000426995.2 Gencode Gene: ENSG00000175564.13 Transcript (Including UTRs) Position: hg38 chr11:74,003,448-74,009,085 Size: 5,638 Total Exon Count: 6 Strand: - Coding Region Position: hg38 chr11:74,003,823-74,007,042 Size: 3,220 Coding Exon Count: 5
ID:UCP3_HUMAN DESCRIPTION: RecName: Full=Mitochondrial uncoupling protein 3; Short=UCP 3; AltName: Full=Solute carrier family 25 member 9; FUNCTION: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance. SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity). TISSUE SPECIFICITY: Only in skeletal muscle and heart. Is more expressed in glycolytic than in oxidative skeletal muscles. DISEASE: Defects in UCP3 may be involved in obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. SIMILARITY: Belongs to the mitochondrial carrier family. SIMILARITY: Contains 3 Solcar repeats. SEQUENCE CAUTION: Sequence=AAC51785.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00153 - Mitochondrial carrier protein
ModBase Predicted Comparative 3D Structure on P55916
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
KJ904584 - Synthetic construct Homo sapiens clone ccsbBroadEn_13978 UCP3-like gene, encodes complete protein. BC008392 - Homo sapiens uncoupling protein 3 (mitochondrial, proton carrier), mRNA (cDNA clone MGC:14479 IMAGE:4291158), complete cds. U84763 - Homo sapiens UCP3 mRNA, complete cds. AF011449 - Homo sapiens uncoupling protein-3 (UCP3) mRNA, nuclear gene encoding mitochondrial protein, complete cds. AF001787 - Homo sapiens uncoupling protein 3 mRNA, complete cds. AB529052 - Synthetic construct DNA, clone: pF1KB3659, Homo sapiens UCP3 gene for uncoupling protein 3, without stop codon, in Flexi system. KU178371 - Homo sapiens uncoupling protein 3 isoform 1 (UCP3) mRNA, partial cds, alternatively spliced. KU178372 - Homo sapiens uncoupling protein 3 isoform 2 (UCP3) mRNA, partial cds. AK092685 - Homo sapiens cDNA FLJ35366 fis, clone SKMUS2001215, highly similar to MITOCHONDRIAL UNCOUPLING PROTEIN 3. AK309873 - Homo sapiens cDNA, FLJ99914. U82818 - Homo sapiens UCP3S mRNA, complete cds. AK291889 - Homo sapiens cDNA FLJ78613 complete cds, highly similar to Homo sapiens uncoupling protein 3 (mitochondrial, proton carrier) (UCP3), transcript variant short, mRNA. AK290630 - Homo sapiens cDNA FLJ77071 complete cds, highly similar to Homo sapiens uncoupling protein 3 (mitochondrial, proton carrier) (UCP3), transcript variant short, mRNA. JD485230 - Sequence 466254 from Patent EP1572962. JD366891 - Sequence 347915 from Patent EP1572962. JD151029 - Sequence 132053 from Patent EP1572962. JD398880 - Sequence 379904 from Patent EP1572962. JD190556 - Sequence 171580 from Patent EP1572962. CU678945 - Synthetic construct Homo sapiens gateway clone IMAGE:100020175 5' read UCP3 mRNA. JD108857 - Sequence 89881 from Patent EP1572962. JD436872 - Sequence 417896 from Patent EP1572962. JD355192 - Sequence 336216 from Patent EP1572962. JD449686 - Sequence 430710 from Patent EP1572962. JD085410 - Sequence 66434 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P55916 (Reactome details) participates in the following event(s):
R-HSA-166220 FA anion diffuses laterally to UCP R-HSA-166387 The FA anion diffuses away laterally from UCP R-HSA-166214 FA anion flip-flops to the opposite surface R-HSA-170026 Protons are translocated from the intermembrane space to the matrix R-HSA-167826 The fatty acid cycling model R-HSA-166187 Mitochondrial Uncoupling Proteins R-HSA-167827 The proton buffering model R-HSA-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport R-HSA-1430728 Metabolism
US Server
