Human Gene PGR (ENST00000325455.10) from GENCODE V44
  Description: Homo sapiens progesterone receptor (PGR), transcript variant 4, non-coding RNA. (from RefSeq NR_073141)
RefSeq Summary (NM_000926): This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce several transcript variants, both protein coding and non-protein coding. Two of the isoforms (A and B) are identical except for an additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Sep 2015].
Gencode Transcript: ENST00000325455.10
Gencode Gene: ENSG00000082175.16
Transcript (Including UTRs)
   Position: hg38 chr11:101,029,624-101,129,813 Size: 100,190 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg38 chr11:101,039,116-101,129,070 Size: 89,955 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:101,029,624-101,129,813)mRNA (may differ from genome)Protein (933 aa)
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OMIMPubMedReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: PRGR_HUMAN
DESCRIPTION: RecName: Full=Progesterone receptor; Short=PR; AltName: Full=Nuclear receptor subfamily 3 group C member 3;
FUNCTION: The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.
FUNCTION: Isoform A is inactive in stimulating c-Src/MAPK signaling on hormone stimulation.
SUBUNIT: Interacts with SMARD1 and UNC45A. Interacts with CUEDC2; the interaction promotes ubiquitination, decreases sumoylation, and repesses transcriptional activity. Interacts with PIAS3; the interaction promotes sumoylation of PR in a hormone-dependent manner, inhibits DNA-binding, and alters nuclear export. Interacts with SP1; the interaction requires ligand-induced phosphorylation on Ser-345 by ERK1/2 MAPK. Interacts with PRMT2.
INTERACTION: Q9H467:CUEDC2; NbExp=9; IntAct=EBI-78539, EBI-1248228; P40763:STAT3; NbExp=3; IntAct=EBI-78539, EBI-518675;
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Nucleoplasmic shuttling is both homone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases.
SUBCELLULAR LOCATION: Isoform A: Nucleus. Cytoplasm. Note=Mainly nuclear.
DOMAIN: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
PTM: Phosphorylated on multiple serine sites. Several of these sites are hormone-dependent. Phosphorylation on Ser-294 occurs preferentially on isoform B, is highly hormone-dependent and modulates ubiquitination and sumoylation on Lys-388. Phosphorylation on Ser-102 and Ser-345 also requires induction by hormone. Basal phosphorylation on Ser-81, Ser-162, Ser-190 and Ser-400 is increased in response to progesterone and can be phosphorylated in vitro by the CDK2-A1 complex. Increased levels of phosphorylation on Ser-400 also in the presence of EGF, heregulin, IGF, PMA and FBS. Phosphorylation at this site by CDK2 is ligand-independent, and increases nuclear translocation and transcriptional activity. Phosphorylation at Ser-162 and Ser-294, but not at Ser-190, is impaired during the G(2)/M phase of the cell cycle. Phosphorylation on Ser-345 by ERK1/2 MAPK is required for interaction with SP1.
PTM: Sumoylation is hormone-dependent and represses transcriptional activity. Sumoylation on all three sites is enhanced by PIAS3. Desumoylated by SENP1. Sumoylation on Lys-388, the main site of sumoylation, is repressed by ubiquitination on the same site, and modulated by phosphorylation at Ser-294.
PTM: Ubiquitination is hormone-dependent and represses sumoylation on the same site. Promoted by MAPK-mediated phosphorylation on Ser-294.
PTM: Palmitoylated by ZDHHC7 and ZDHHC21. Palmitoylation is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation.
SIMILARITY: Belongs to the nuclear hormone receptor family. NR3 subfamily.
SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/pgr/";
WEB RESOURCE: Name=Wikipedia; Note=Progesterone receptor entry; URL="http://en.wikipedia.org/wiki/Progesterone_receptor";

-  Primer design for this transcript
 

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-  MalaCards Disease Associations
  MalaCards Gene Search: PGR
Diseases sorted by gene-association score: progesterone resistance* (77), myoma (37), female breast cancer (30), microglandular adenosis (29), smooth muscle tumor (29), endometrial adenocarcinoma (26), endometriosis (25), progesterone-receptor negative breast cancer (23), bizarre leiomyoma (23), cribriform carcinoma (22), breast cancer (22), papillary serous adenocarcinoma (22), breast scirrhous carcinoma (22), trigonitis (21), vulvar dystrophy (21), endosalpingiosis (21), leiomyoma (20), sertoli-leydig cell tumor (20), adenosarcoma (20), endometrial cancer (19), glassy cell carcinoma of the cervix (18), bartholin's gland benign neoplasm (18), in situ carcinoma (18), breast fibroadenoma (17), progesterone-receptor positive breast cancer (17), breast benign neoplasm (16), thoracic benign neoplasm (16), serous cystadenocarcinoma (16), spindle cell carcinoma (16), malignant mixed mullerian tumor (15), breast ductal carcinoma (15), vulvar benign neoplasm (15), scirrhous adenocarcinoma (14), prostate stromal sarcoma (14), endometrium carcinoma in situ (14), leiomyomatosis (14), vestibular gland benign neoplasm (14), cervical adenosarcoma (14), granulomatous endometritis (14), bartholin's gland adenoma (14), lymphangioleiomyomatosis (14), bartholin's gland adenocarcinoma (14), angiomyolipoma (14), estrogen excess (13), ductal carcinoma in situ (13), leiomyosarcoma (13), cystic nephroma (13), uterine fibroid (13), papillary adenocarcinoma (13), benign metastasizing leiomyoma (13), adenomyosis (13), benign meningioma (13), pleomorphic lipoma (13), myxoid leiomyosarcoma (13), endometrial stromal sarcoma (13), epulis (12), endometrial mucinous adenocarcinoma (12), estrogen-receptor positive breast cancer (12), muscle cancer (12), sex cord-gonadal stromal tumor (12), phyllode tumor (12), meningioma, familial (12), cystadenocarcinoma (12), estrogen-receptor negative breast cancer (12), fallopian tube carcinoma (11), ovarian serous cystadenocarcinoma (11), vulvar syringoma (11), clear cell meningioma (11), juvenile nasopharyngeal angiofibroma (11), gender identity disorder (10), sweat gland cancer (10), congenital epulis (10), ovarian cancer, somatic (10), pre-malignant neoplasm (10), lung leiomyoma (10), breast duct papilloma (10), uterine carcinosarcoma (10), endometrial squamous cell carcinoma (10), breast disease (10), perivascular epithelioid cell tumor (10), breast mucoepidermoid carcinoma (10), vulvar leiomyoma (10), gynecomastia (10), mixed hepatoblastoma (10), uterine benign neoplasm (10), reproductive organ benign neoplasm (10), pneumothorax (9), female reproductive endometrioid cancer (9), inflammatory breast carcinoma (9), endometritis (9), sporadic breast cancer (9), apocrine adenocarcinoma (9), tubular adenocarcinoma (9), breast metaplastic carcinoma (9), fibromuscular dysplasia (9), chickenpox (9), lymphangiomatosis (9), benign breast phyllodes tumor (9), mammary paget's disease (8), progressive relapsing multiple sclerosis (8), bilateral breast cancer (8), lung meningioma (8), dermoid cyst (8), predominantly cortical thymoma (8), oncocytic breast carcinoma (8), prostatic hypertrophy (8), cystadenoma (8), adenoid basal cell carcinoma (8), papillary carcinoma (7), fibromatosis (7), pleomorphic carcinoma (7), glycogen-rich clear cell breast carcinoma (7), papillary hidradenoma (7), endometrial stromal nodule (7), luminal breast carcinoma (7), nosophobia (7), cancerophobia (7), intracystic papillary adenoma (7), female reproductive organ cancer (7), deep angioma (7), primary peritoneal carcinoma (7), breast papillary carcinoma (7), lipid-rich carcinoma (7), cervical clear cell adenocarcinoma (6), uterine corpus cancer (6), lymphoplasmacyte-rich meningioma (6), breast medullary carcinoma (6), gastric signet ring cell adenocarcinoma (6), cervical carcinosarcoma (6), intramuscular hemangioma (6), breast malignant phyllodes tumor (6), angiomatous meningioma (6), olfactory groove meningioma (6), adenomyoma (6), synchronous bilateral breast carcinoma (5), retroperitoneal leiomyosarcoma (5), retinitis pigmentosa 20 (5), primary pigmented nodular adrenocortical disease (5), spinal canal and spinal cord meningioma (5), mixed cell type cancer (5), pancreatic mucinous cystadenoma (5), pancreatic serous cystadenoma (5), endometriosis of ovary (5), breast carcinoma in situ (5), breast adenoid cystic carcinoma (5), anterior cranial fossa meningioma (5), female reproductive system disease (5), corneal abscess (5), breast mucinous carcinoma (5), dysgerminoma of ovary (5), premenstrual tension (5), uterine body mixed cancer (5), spinal meningioma (5), sella turcica neoplasm (5), tuberculum sellae meningioma (5), retinitis pigmentosa 47 (5), non-gestational choriocarcinoma (5), breast squamous cell carcinoma (5), breast angiosarcoma (5), noma (5), triple-receptor negative breast cancer (5), infertility (4), breast secretory carcinoma (4), spermatocele (4), reproductive organ cancer (2), reproductive system disease (2), organ system benign neoplasm (1), cell type cancer (1), malignant ovarian surface epithelial-stromal neoplasm (1), ovary epithelial cancer (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 30.49 RPKM in Cervix - Endocervix
Total median expression: 144.48 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -277.00743-0.373 Picture PostScript Text
3' UTR -2294.209492-0.242 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008946 - Nucl_hormone_rcpt_ligand-bd
IPR000536 - Nucl_hrmn_rcpt_lig-bd_core
IPR000128 - Progest_rcpt
IPR001723 - Str_hrmn_rcpt
IPR001628 - Znf_hrmn_rcpt
IPR013088 - Znf_NHR/GATA

Pfam Domains:
PF00104 - Ligand-binding domain of nuclear hormone receptor
PF02161 - Progesterone receptor
PF00105 - Zinc finger, C4 type (two domains)

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1A28 - X-ray MuPIT 1E3K - X-ray MuPIT 1SQN - X-ray MuPIT 1SR7 - X-ray MuPIT 1ZUC - X-ray MuPIT 2C7A - X-ray MuPIT 2OVH - X-ray MuPIT 2OVM - X-ray MuPIT 2W8Y - X-ray MuPIT 3D90 - X-ray MuPIT 3G8O - X-ray MuPIT 3HQ5 - X-ray MuPIT 3KBA - X-ray MuPIT 3ZR7 - X-ray MuPIT 3ZRA - X-ray MuPIT 3ZRB - X-ray MuPIT 4A2J - X-ray MuPIT 4APU - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P06401
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein SequenceProtein Sequence   
AlignmentAlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0003707 steroid hormone receptor activity
GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
GO:0005102 receptor binding
GO:0005496 steroid binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0008289 lipid binding
GO:0019899 enzyme binding
GO:0042802 identical protein binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
GO:0051117 ATPase binding

Biological Process:
GO:0001542 ovulation from ovarian follicle
GO:0002070 epithelial cell maturation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0010629 negative regulation of gene expression
GO:0030879 mammary gland development
GO:0038001 paracrine signaling
GO:0043401 steroid hormone mediated signaling pathway
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048286 lung alveolus development
GO:0050678 regulation of epithelial cell proliferation
GO:0050847 progesterone receptor signaling pathway
GO:0060748 tertiary branching involved in mammary gland duct morphogenesis

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005829 cytosol
GO:0016020 membrane


-  Descriptions from all associated GenBank mRNAs
  LF385523 - JP 2014500723-A/193026: Polycomb-Associated Non-Coding RNAs.
MA621100 - JP 2018138019-A/193026: Polycomb-Associated Non-Coding RNAs.
X51730 - Human mRNA and promoter DNA for progesterone receptor.
AK304853 - Homo sapiens cDNA FLJ51472 complete cds, highly similar to Progesterone receptor.
AY212933 - Homo sapiens truncated progesterone receptor mRNA, complete cds.
AF016381 - Homo sapiens progesterone receptor (PR) mRNA, complete cds.
M15716 - Human progesterone receptor mRNA, complete cds.
AB084248 - Homo sapiens PR mRNA for delta 4 progesterone receptor, complete cds.
AB085683 - Homo sapiens PR mRNA for Progesterone receptor, complete cds.
AB085843 - Homo sapiens PR mRNA for delta 3+6/2 progesterone receptor, complete cds.
AB085844 - Homo sapiens PR mRNA for delta4+6/2 progesterone receptor, complete cds.
AB085845 - Homo sapiens PR mRNA for delta 6/2 progesterone receptor, complete cds.
BC152914 - Synthetic construct Homo sapiens clone IMAGE:100016179, MGC:184155 progesterone receptor (PGR) mRNA, encodes complete protein.
AB587507 - Synthetic construct DNA, clone: pF1KB9766, Homo sapiens PGR gene for progesterone receptor, without stop codon, in Flexi system.
AY382151 - Homo sapiens progesterone receptor mRNA, partial cds.
AL137566 - Homo sapiens mRNA; cDNA DKFZp586G0321 (from clone DKFZp586G0321).
LF212258 - JP 2014500723-A/19761: Polycomb-Associated Non-Coding RNAs.
MA447835 - JP 2018138019-A/19761: Polycomb-Associated Non-Coding RNAs.
LF208370 - JP 2014500723-A/15873: Polycomb-Associated Non-Coding RNAs.
MA443947 - JP 2018138019-A/15873: Polycomb-Associated Non-Coding RNAs.
LF213148 - JP 2014500723-A/20651: Polycomb-Associated Non-Coding RNAs.
MA448725 - JP 2018138019-A/20651: Polycomb-Associated Non-Coding RNAs.
LF375570 - JP 2014500723-A/183073: Polycomb-Associated Non-Coding RNAs.
MA611147 - JP 2018138019-A/183073: Polycomb-Associated Non-Coding RNAs.
AY382152 - Homo sapiens progesterone receptor B isoform mRNA, partial cds.
JD408956 - Sequence 389980 from Patent EP1572962.
JD050981 - Sequence 32005 from Patent EP1572962.
JD357447 - Sequence 338471 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04114 - Oocyte meiosis
hsa04914 - Progesterone-mediated oocyte maturation

BioCarta from NCI Cancer Genome Anatomy Project
h_mPRPathway - How Progesterone Initiates the Oocyte Maturation

Reactome (by CSHL, EBI, and GO)

Protein P06401 (Reactome details) participates in the following event(s):

R-HSA-376419 Formation of NR-MED1 Coactivator Complex
R-HSA-383280 Nuclear Receptor transcription pathway
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
R-HSA-376419 Formation of NR-MED1 Coactivator Complex
R-HSA-5618099 SH binds SHR within the HSP90 chaperone complex
R-HSA-1251985 Nuclear signaling by ERBB4
R-HSA-9018519 Estrogen-dependent gene expression
R-HSA-383280 Nuclear Receptor transcription pathway
R-HSA-1236394 Signaling by ERBB4
R-HSA-8939211 ESR-mediated signaling
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-HSA-212436 Generic Transcription Pathway
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9006931 Signaling by Nuclear Receptors
R-HSA-2262752 Cellular responses to stress
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-162582 Signal Transduction
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: A7X8B0, ENST00000325455.1, ENST00000325455.2, ENST00000325455.3, ENST00000325455.4, ENST00000325455.5, ENST00000325455.6, ENST00000325455.7, ENST00000325455.8, ENST00000325455.9, NR3C3, NR_073141, P06401, PRGR_HUMAN, Q9UPF7, uc001pgh.1, uc001pgh.2, uc001pgh.3, uc001pgh.4
UCSC ID: ENST00000325455.10
RefSeq Accession: NM_000926
Protein: P06401 (aka PRGR_HUMAN)
CCDS: CCDS8310.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.