Human Gene TMEM123 (ENST00000398136.7) from GENCODE V44
Description: Homo sapiens transmembrane protein 123 (TMEM123), mRNA. (from RefSeq NM_052932) RefSeq Summary (NM_052932): This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000398136.7 Gencode Gene: ENSG00000152558.15 Transcript (Including UTRs) Position: hg38 chr11:102,396,332-102,452,765 Size: 56,434 Total Exon Count: 5 Strand: - Coding Region Position: hg38 chr11:102,398,867-102,452,623 Size: 53,757 Coding Exon Count: 5
ID:PORIM_HUMAN DESCRIPTION: RecName: Full=Porimin; AltName: Full=Keratinocytes-associated transmembrane protein 3; Short=KCT-3; AltName: Full=Pro-oncosis receptor inducing membrane injury; AltName: Full=Transmembrane protein 123; Flags: Precursor; FUNCTION: Implicated in oncotic cell death, characterized by cell swelling, organelle swelling, vacuolization and increased membrane permeability. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential). TISSUE SPECIFICITY: Ubiquitous. Not expressed in ovary. Expressed in keratinocytes. SIMILARITY: Belongs to the CD164 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
ModBase Predicted Comparative 3D Structure on Q8N131
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
