Human Gene GRIA4 (ENST00000525032.1) from GENCODE V44
  Description: glutamate ionotropic receptor AMPA type subunit 4 (from HGNC GRIA4)
RefSeq Summary (NM_001112812): Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000525032.1
Gencode Gene: ENSG00000152578.15
Transcript (Including UTRs)
   Position: hg38 chr11:105,610,672-105,862,649 Size: 251,978 Total Exon Count: 4 Strand: +


Page IndexSequence and LinksPrimersMalaCardsCTDRNA-Seq Expression
Microarray ExpressionOther SpeciesmRNA DescriptionsPathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:105,610,672-105,862,649)mRNA (may differ from genome)No protein
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
EnsemblExonPrimerGencodeHGNCLynxMalacards
PubMedWikipedia

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: GRIA4
Diseases sorted by gene-association score: schizophrenia (3)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 22.35 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 101.75 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  BC045546 - Homo sapiens glutamate receptor, ionotrophic, AMPA 4, mRNA (cDNA clone IMAGE:5265048), complete cds.
BC142654 - Homo sapiens glutamate receptor, ionotrophic, AMPA 4, mRNA (cDNA clone IMAGE:40148067), complete cds.
BC150209 - Homo sapiens glutamate receptor, ionotrophic, AMPA 4, mRNA (cDNA clone IMAGE:40148893), complete cds.
AB209092 - Homo sapiens mRNA for glutamate receptor, ionotrophic variant protein.
BC146816 - Homo sapiens glutamate receptor, ionotrophic, AMPA 4, mRNA (cDNA clone IMAGE:8860412), complete cds.
BC167786 - Synthetic construct Homo sapiens clone IMAGE:100068176, MGC:195793 glutamate receptor, ionotrophic, AMPA 4 (GRIA4) mRNA, encodes complete protein.
U16129 - Human glutamate receptor (GluR4) mRNA, complete cds.
BC114549 - Homo sapiens glutamate receptor, ionotrophic, AMPA 4, mRNA (cDNA clone IMAGE:40034913), partial cds.
BC015199 - Homo sapiens glutamate receptor, ionotrophic, AMPA 4, mRNA (cDNA clone IMAGE:4277248), with apparent retained intron.
BC035610 - Homo sapiens glutamate receptor, ionotrophic, AMPA 4, mRNA (cDNA clone IMAGE:5199898), with apparent retained intron.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04080 - Neuroactive ligand-receptor interaction

-  Other Names for This Gene
  Alternate Gene Symbols: BC015199, uc001piv.1, uc001piv.2, uc001piv.3, uc001piv.4, uc001piv.5
UCSC ID: ENST00000525032.1
RefSeq Accession: NM_001112812

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.