Human Gene TMPRSS13 (ENST00000524993.6) from GENCODE V44
Description: Homo sapiens transmembrane serine protease 13 (TMPRSS13), transcript variant 1, mRNA. (from RefSeq NM_001077263) RefSeq Summary (NM_001077263): This gene encodes a member of the type II transmembrane serine protease family. Transmembrane serine proteases are regulated by protease inhibitors and known to function in development, homeostasis, infection, and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]. Gencode Transcript: ENST00000524993.6 Gencode Gene: ENSG00000137747.16 Transcript (Including UTRs) Position: hg38 chr11:117,900,641-117,929,402 Size: 28,762 Total Exon Count: 13 Strand: - Coding Region Position: hg38 chr11:117,902,239-117,929,307 Size: 27,069 Coding Exon Count: 13
ID:TMPSD_HUMAN DESCRIPTION: RecName: Full=Transmembrane protease serine 13; EC=3.4.21.-; AltName: Full=Membrane-type mosaic serine protease; Short=Mosaic serine protease; SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein (Potential). TISSUE SPECIFICITY: Isoform 1 and isoform 3 are predominantly expressed in lung, placenta, pancreas, and prostate. Isoform 3 is weakly expressed in testis and peripheral blood lymphocytes. POLYMORPHISM: The repeat A-S-P-A-[GLQR] is polymorphic and the number of copies varies between 12 to 14. SIMILARITY: Belongs to the peptidase S1 family. SIMILARITY: Contains 1 LDL-receptor class A domain. SIMILARITY: Contains 1 peptidase S1 domain. SIMILARITY: Contains 1 SRCR domain. CAUTION: Was termed TMPRSS6 (Ref.3).
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BYE2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
