Human Gene KLRD1 (ENST00000336164.9) from GENCODE V44
Description: Homo sapiens killer cell lectin like receptor D1 (KLRD1), transcript variant 9, non-coding RNA. (from RefSeq NR_147040) RefSeq Summary (NM_002262): Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2017]. Gencode Transcript: ENST00000336164.9 Gencode Gene: ENSG00000134539.17 Transcript (Including UTRs) Position: hg38 chr12:10,307,870-10,329,608 Size: 21,739 Total Exon Count: 6 Strand: + Coding Region Position: hg38 chr12:10,308,078-10,314,793 Size: 6,716 Coding Exon Count: 6
ID:KLRD1_HUMAN DESCRIPTION: RecName: Full=Natural killer cells antigen CD94; AltName: Full=KP43; AltName: Full=Killer cell lectin-like receptor subfamily D member 1; AltName: Full=NK cell receptor; AltName: CD_antigen=CD94; FUNCTION: Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. SUBUNIT: Can form disulfide-bonded heterodimer with NKG2 family members. SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein. TISSUE SPECIFICITY: Natural killer cells. SIMILARITY: Contains 1 C-type lectin domain. WEB RESOURCE: Name=Functional Glycomics Gateway - Glycan Binding; Note=CD94; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_238";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q13241
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004888 transmembrane signaling receptor activity GO:0005515 protein binding GO:0023024 MHC class I protein complex binding GO:0023030 MHC class Ib protein binding, via antigen binding groove GO:0030246 carbohydrate binding GO:1990405 protein antigen binding
US Server
