ID:FGOP2_HUMAN DESCRIPTION: RecName: Full=FGFR1 oncogene partner 2; FUNCTION: May be involved in wound healing pathway (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). TISSUE SPECIFICITY: Expressed in bone marrow, spleen and thymus. DISEASE: Note=A chromosomal aberration involving FGFR1OP2 may be a cause of stem cell myeloproliferative disorder (MPD). Insertion ins(12;8)(p11;p11p22) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion protein FGFR1OP2-FGFR1 may exhibit constitutive kinase activity and be responsible for the transforming activity. SIMILARITY: Belongs to the SIKE family. SEQUENCE CAUTION: Sequence=AAF29087.1; Type=Frameshift; Positions=61, 67, 72, 91; Sequence=CAB56012.1; Type=Frameshift; Positions=189;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NVK5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
