Human Gene TWF1 (ENST00000395510.7) from GENCODE V44
Description: Homo sapiens twinfilin actin binding protein 1 (TWF1), transcript variant 2, mRNA. (from RefSeq NM_002822) RefSeq Summary (NM_002822): This gene encodes twinfilin, an actin monomer-binding protein conserved from yeast to mammals. Studies of the mouse counterpart suggest that this protein may be an actin monomer-binding protein, and its localization to cortical G-actin-rich structures may be regulated by the small GTPase RAC1. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000395510.7 Gencode Gene: ENSG00000151239.14 Transcript (Including UTRs) Position: hg38 chr12:43,793,723-43,806,317 Size: 12,595 Total Exon Count: 9 Strand: - Coding Region Position: hg38 chr12:43,795,585-43,806,245 Size: 10,661 Coding Exon Count: 9
ID:TWF1_HUMAN DESCRIPTION: RecName: Full=Twinfilin-1; AltName: Full=Protein A6; AltName: Full=Protein tyrosine kinase 9; FUNCTION: Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles (By similarity). SUBUNIT: Interacts with G-actin; ADP-actin form and capping protein (CP). May also be able to interact with TWF2 and phosphoinositides, PI(4,5)P2. When bound to PI(4,5)P2, it is down- regulated (By similarity). SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton (By similarity). Note=Diffuse cytoplasmic localization with perinuclear and G-actin-rich cortical actin structures sublocalization. Also found at membrane ruffles and cell-cell contacts (By similarity). TISSUE SPECIFICITY: Expressed at high levels in the colon, testis, ovary, prostate and lung. Expressed at lower levels in the brain, bladder and heart. Not detected in liver. PTM: Phosphorylated on serine and threonine residues. SIMILARITY: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily. SIMILARITY: Contains 2 ADF-H domains. CAUTION: Was originally (PubMed:7507208) thought to have protein tyrosine kinase activity. SEQUENCE CAUTION: Sequence=AAH43148.2; Type=Erroneous initiation; Sequence=AAH68548.1; Type=Erroneous initiation; Sequence=BAD92539.1; Type=Erroneous initiation; WEB RESOURCE: Name=Protein Spotlight; Note=Molecular embrace - Issue 73 of August 2006; URL="http://web.expasy.org/spotlight/back_issues/sptlt073.shtml";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00241 - Cofilin/tropomyosin-type actin-binding protein
ModBase Predicted Comparative 3D Structure on Q12792
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
