Human Gene KRT71 (ENST00000267119.6) from GENCODE V44
Description: Homo sapiens keratin 71 (KRT71), mRNA. (from RefSeq NM_033448) RefSeq Summary (NM_033448): Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes a protein that is expressed in the inner root sheath of hair follicles. The type II keratins are clustered in a region of chromosome 12q13.[provided by RefSeq, Jun 2009]. Gencode Transcript: ENST00000267119.6 Gencode Gene: ENSG00000139648.7 Transcript (Including UTRs) Position: hg38 chr12:52,543,909-52,553,145 Size: 9,237 Total Exon Count: 9 Strand: - Coding Region Position: hg38 chr12:52,544,532-52,553,077 Size: 8,546 Coding Exon Count: 9
ID:K2C71_HUMAN DESCRIPTION: RecName: Full=Keratin, type II cytoskeletal 71; AltName: Full=Cytokeratin-71; Short=CK-71; AltName: Full=Keratin-71; Short=K71; AltName: Full=Type II inner root sheath-specific keratin-K6irs1; Short=Keratin 6 irs; Short=hK6irs; Short=hK6irs1; AltName: Full=Type-II keratin Kb34; FUNCTION: Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable). SUBUNIT: Heterodimer of a type I and a type II keratin. Associates with KRT16 and/or KRT17 (By similarity). TISSUE SPECIFICITY: Highly expressed in hair follicles from scalp. Specifically expressed in the inner root sheath (IRS) of the hair follicle. Present in the all 3 IRS layers: the cuticle, the Henle and the Huxley layers. Also detected in the pseudopods of specialized Huxley cells, termed Fluegelzellen, along the area of differentiated Henle cells (at protein level). DEVELOPMENTAL STAGE: In all 3 IRS layers, expression begins simultaneously in adjacent cells of the lowermost bulb above the germinative cell pool and terminated higher up in the follicle with the asynchronous terminal differentiation of each cell layer (at protein level). MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40- 55 and 56-70 kDa, respectively). SIMILARITY: Belongs to the intermediate filament family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00038 - Intermediate filament protein
ModBase Predicted Comparative 3D Structure on Q3SY84
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
