Human Gene ZNF740 (ENST00000416904.5) from GENCODE V44
  Description: Homo sapiens zinc finger protein 740 (ZNF740), mRNA. (from RefSeq NM_001004304)
Gencode Transcript: ENST00000416904.5
Gencode Gene: ENSG00000139651.11
Transcript (Including UTRs)
   Position: hg38 chr12:53,180,722-53,195,142 Size: 14,421 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg38 chr12:53,181,984-53,187,590 Size: 5,607 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:53,180,722-53,195,142)mRNA (may differ from genome)Protein (193 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
PubMedReactomeUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZN740_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 740; AltName: Full=OriLyt TD-element-binding protein 7;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Probable).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 3 C2H2-type zinc fingers.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 15.48 RPKM in Brain - Cerebellum
Total median expression: 452.82 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -148.90423-0.352 Picture PostScript Text
3' UTR -2824.657552-0.374 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

ModBase Predicted Comparative 3D Structure on Q8NDX6
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein SequenceProtein Sequence   
AlignmentAlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AK292744 - Homo sapiens cDNA FLJ75383 complete cds, highly similar to Homo sapiens zinc finger protein 740, mRNA.
BC053557 - Homo sapiens zinc finger protein 740, mRNA (cDNA clone MGC:61706 IMAGE:6162269), complete cds.
JD489931 - Sequence 470955 from Patent EP1572962.
JD339788 - Sequence 320812 from Patent EP1572962.
JD109296 - Sequence 90320 from Patent EP1572962.
AK091946 - Homo sapiens cDNA FLJ34627 fis, clone KIDNE2015445, weakly similar to Mus musculus transcription factor BFCOL1 mRNA.
JD191341 - Sequence 172365 from Patent EP1572962.
JD267353 - Sequence 248377 from Patent EP1572962.
JD364286 - Sequence 345310 from Patent EP1572962.
JD151122 - Sequence 132146 from Patent EP1572962.
JD400592 - Sequence 381616 from Patent EP1572962.
JD320989 - Sequence 302013 from Patent EP1572962.
JD497289 - Sequence 478313 from Patent EP1572962.
JD226170 - Sequence 207194 from Patent EP1572962.
JD248859 - Sequence 229883 from Patent EP1572962.
JD415307 - Sequence 396331 from Patent EP1572962.
JD049397 - Sequence 30421 from Patent EP1572962.
JD506151 - Sequence 487175 from Patent EP1572962.
JD237995 - Sequence 219019 from Patent EP1572962.
JD487402 - Sequence 468426 from Patent EP1572962.
JD561465 - Sequence 542489 from Patent EP1572962.
JD276173 - Sequence 257197 from Patent EP1572962.
JD122819 - Sequence 103843 from Patent EP1572962.
JD037600 - Sequence 18624 from Patent EP1572962.
JD511401 - Sequence 492425 from Patent EP1572962.
JD225530 - Sequence 206554 from Patent EP1572962.
JD385714 - Sequence 366738 from Patent EP1572962.
JD556976 - Sequence 538000 from Patent EP1572962.
JD254327 - Sequence 235351 from Patent EP1572962.
JD423547 - Sequence 404571 from Patent EP1572962.
AF086252 - Homo sapiens full length insert cDNA clone ZD40B09.
JD091840 - Sequence 72864 from Patent EP1572962.
JD070375 - Sequence 51399 from Patent EP1572962.
JD061646 - Sequence 42670 from Patent EP1572962.
JD039530 - Sequence 20554 from Patent EP1572962.
JD214334 - Sequence 195358 from Patent EP1572962.
JD124492 - Sequence 105516 from Patent EP1572962.
JD263641 - Sequence 244665 from Patent EP1572962.
JD252236 - Sequence 233260 from Patent EP1572962.
JD178183 - Sequence 159207 from Patent EP1572962.
JD264881 - Sequence 245905 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8NDX6 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: A8K9M9, ENST00000416904.1, ENST00000416904.2, ENST00000416904.3, ENST00000416904.4, NM_001004304, Q8NDX6, TB7, uc001scb.1, uc001scb.2, uc001scb.3, uc001scb.4, uc001scb.5, uc001scb.6, ZN740_HUMAN
UCSC ID: ENST00000416904.5
RefSeq Accession: NM_001004304
Protein: Q8NDX6 (aka ZN740_HUMAN)
CCDS: CCDS44896.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.