ID:EEA1_HUMAN DESCRIPTION: RecName: Full=Early endosome antigen 1; AltName: Full=Endosome-associated protein p162; AltName: Full=Zinc finger FYVE domain-containing protein 2; FUNCTION: Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. SUBUNIT: Homodimer. Binds STX6. Binds RAB5A, RAB5B, RAB5C and RAB22A that have been activated by GTP-binding. Interacts with ERBB2. INTERACTION: P04626:ERBB2; NbExp=5; IntAct=EBI-298113, EBI-641062; Q9UL26:RAB22A; NbExp=3; IntAct=EBI-298113, EBI-399456; P20339:RAB5A; NbExp=3; IntAct=EBI-298113, EBI-399437; P61020:RAB5B; NbExp=3; IntAct=EBI-298113, EBI-399401; Q63635:Stx6 (xeno); NbExp=4; IntAct=EBI-298113, EBI-398854; SUBCELLULAR LOCATION: Cytoplasm. Early endosome membrane; Peripheral membrane protein. DOMAIN: The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate in membranes of early endosomes and penetrates bilayers. The FYVE domain insertion into PtdIns(3)P-enriched membranes is substantially increased in acidic conditions. MISCELLANEOUS: Antibodies against EEA1 are found in sera from patients with subacute cutaneous lupus erythematosus and other autoimmune diseases. SIMILARITY: Contains 1 C2H2-type zinc finger. SIMILARITY: Contains 1 FYVE-type zinc finger.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q15075
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006897 endocytosis GO:0006906 vesicle fusion GO:0016189 synaptic vesicle to endosome fusion GO:0039694 viral RNA genome replication GO:0045022 early endosome to late endosome transport
L40157 - Human endosome-associated protein (EEA1) mRNA, complete cds. X78998 - H.sapiens p162 mRNA. BC172504 - Synthetic construct Homo sapiens clone IMAGE:100069198, MGC:199209 early endosome antigen 1 (EEA1) mRNA, encodes complete protein. BC156545 - Synthetic construct Homo sapiens clone IMAGE:100063241, MGC:190721 early endosome antigen 1 (EEA1) mRNA, encodes complete protein. BC041930 - Homo sapiens cDNA clone IMAGE:5300538. BX648463 - Homo sapiens mRNA; cDNA DKFZp686O14119 (from clone DKFZp686O14119). AF173389 - Homo sapiens MSTP105 (MST105) mRNA, complete cds. JD032251 - Sequence 13275 from Patent EP1572962. JD027147 - Sequence 8171 from Patent EP1572962. JD060895 - Sequence 41919 from Patent EP1572962. JD191665 - Sequence 172689 from Patent EP1572962. AK307918 - Homo sapiens cDNA, FLJ97866. AK292008 - Homo sapiens cDNA FLJ75535 partial cds, highly similar to Homo sapiens early endosome antigen 1, 162kD (EEA1), mRNA. BC017837 - Homo sapiens early endosome antigen 1, mRNA (cDNA clone IMAGE:4270936), partial cds. JD320448 - Sequence 301472 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04144 - Endocytosis
BioCarta from NCI Cancer Genome Anatomy Project h_ptdinsPathway - Phosphoinositides and their downstream targets. h_eea1Pathway - The role of FYVE-finger proteins in vesicle transport
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