Human Gene ELK3 (ENST00000228741.8) from GENCODE V44
Description: Homo sapiens ETS transcription factor ELK3 (ELK3), transcript variant 1, mRNA. (from RefSeq NM_005230) RefSeq Summary (NM_005230): This gene encodes a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]. Gencode Transcript: ENST00000228741.8 Gencode Gene: ENSG00000111145.8 Transcript (Including UTRs) Position: hg38 chr12:96,194,375-96,269,824 Size: 75,450 Total Exon Count: 5 Strand: + Coding Region Position: hg38 chr12:96,223,567-96,267,180 Size: 43,614 Coding Exon Count: 4
ID:ELK3_HUMAN DESCRIPTION: RecName: Full=ETS domain-containing protein Elk-3; AltName: Full=ETS-related protein ERP; AltName: Full=ETS-related protein NET; AltName: Full=Serum response factor accessory protein 2; Short=SAP-2; Short=SRF accessory protein 2; FUNCTION: May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element. SUBUNIT: Interacts with CTBP1. INTERACTION: P16333:NCK1; NbExp=3; IntAct=EBI-1758534, EBI-389883; SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the ETS family. SIMILARITY: Contains 1 ETS DNA-binding domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P41970
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
