ID:IKIP_HUMAN DESCRIPTION: RecName: Full=Inhibitor of nuclear factor kappa-B kinase-interacting protein; Short=I kappa-B kinase-interacting protein; Short=IKBKB-interacting protein; Short=IKK-interacting protein; FUNCTION: Target of p53/TP53 with pro-apoptotic function. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass membrane protein. Note=Isoform 4 deletion of the hydrophobic, or transmembrane region between AA 45-63 results in uniform distribution throughout the cell, suggesting that this region is responsible for endoplasmic reticulum localization. TISSUE SPECIFICITY: Expressed in vein endothelial cells. Isoform 4 is expressed in lung, kidney, spleen, thymus and skeletal muscle. INDUCTION: By X-ray irradiation. PTM: Isoform 4 may be phosphorylated at Thr-362 by similarity with mouse isoform 1. PTM: N-glycosylated. Isoform 4 is glycosylated at Asn-154. MISCELLANEOUS: Shares a common promoter with APAF1 from which the 2 genes are transcribed in opposite directions.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q70UQ0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
