Human Gene NAA25 (ENST00000261745.9) from GENCODE V44
Description: Homo sapiens N-alpha-acetyltransferase 25, NatB auxiliary subunit (NAA25), mRNA. (from RefSeq NM_024953) RefSeq Summary (NM_024953): This gene encodes the auxiliary subunit of the heteromeric N-terminal acetyltransferase B complex. This complex acetylates methionine residues that are followed by acidic or asparagine residues.[provided by RefSeq, Mar 2010]. Gencode Transcript: ENST00000261745.9 Gencode Gene: ENSG00000111300.10 Transcript (Including UTRs) Position: hg38 chr12:112,026,689-112,108,783 Size: 82,095 Total Exon Count: 24 Strand: - Coding Region Position: hg38 chr12:112,029,531-112,108,773 Size: 79,243 Coding Exon Count: 24
ID:NAA25_HUMAN DESCRIPTION: RecName: Full=N-alpha-acetyltransferase 25, NatB auxiliary subunit; AltName: Full=Mitochondrial distribution and morphology protein 20; AltName: Full=N-terminal acetyltransferase B complex subunit MDM20; Short=NatB complex subunit MDM20; AltName: Full=N-terminal acetyltransferase B complex subunit NAA25; AltName: Full=p120; FUNCTION: Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp-Glu. May play a role in normal cell-cycle progression. SUBUNIT: Component of the N-terminal acetyltransferase B (NatB) complex which is composed of NAA20 and NAA25. INTERACTION: P24941:CDK2; NbExp=1; IntAct=EBI-1048503, EBI-375096; SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the MDM20/NAA25 family. SIMILARITY: Contains 4 TPR repeats. SEQUENCE CAUTION: Sequence=BAB14432.1; Type=Erroneous initiation; Sequence=CAE46062.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF09797 - N-acetyltransferase B complex (NatB) non catalytic subunit
ModBase Predicted Comparative 3D Structure on Q14CX7
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
